Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis

Joana F. Fangueiro; Inês R. Marques; Patrícia Severino; Maria Helena A. Santana; Eliana B. Souto

doi:10.1590/S0100-40422012000900025

Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis

Translated title of the contribution: Development, production and characterization of nanocrystals of poorly soluble drugs

Joana F. Fangueiro^*
, Inês R. Marques
, Patrícia Severino
, Maria Helena A. Santana
, Eliana B. Souto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.

Translated title of the contribution	Development, production and characterization of nanocrystals of poorly soluble drugs
Original language	Portuguese
Pages (from-to)	1848-1853
Number of pages	6
Journal	Quimica Nova
Volume	35
Issue number	9
DOIs	https://doi.org/10.1590/S0100-40422012000900025
Publication status	Published - 5 Oct 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

Nancrystals
Microfluidization
High pressure homogenization

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10.1590/S0100-40422012000900025Licence: CC BY

Cite this

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title = "Desenvolvimento, produ{\c c}{\~a}o e caracteriza{\c c}{\~a}o de nanocristais de f{\'a}rmacos pouco sol{\'u}veis",

abstract = "Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.",

keywords = "Nancrystals, Microfluidization, High pressure homogenization",

author = "Fangueiro, \{Joana F.\} and Marques, \{In{\^e}s R.\} and Patr{\'i}cia Severino and Santana, \{Maria Helena A.\} and Souto, \{Eliana B.\}",

year = "2012",

month = oct,

day = "5",

doi = "10.1590/S0100-40422012000900025",

language = "Portuguese",

volume = "35",

pages = "1848--1853",

journal = "Quimica Nova",

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publisher = "Brazilian Chemical Society",

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TY - JOUR

T1 - Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis

AU - Fangueiro, Joana F.

AU - Marques, Inês R.

AU - Severino, Patrícia

AU - Santana, Maria Helena A.

AU - Souto, Eliana B.

PY - 2012/10/5

Y1 - 2012/10/5

N2 - Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.

AB - Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.

KW - Nancrystals

KW - Microfluidization

KW - High pressure homogenization

UR - https://www.scopus.com/pages/publications/84867958857

U2 - 10.1590/S0100-40422012000900025

DO - 10.1590/S0100-40422012000900025

M3 - Article

AN - SCOPUS:84867958857

SN - 0100-4042

VL - 35

SP - 1848

EP - 1853

JO - Quimica Nova

JF - Quimica Nova

IS - 9

ER -

Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis

Abstract

UN SDGs

Keywords

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