Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration

Beatriz G. Bernardes; Clara Sousa; Maria Rosaria Sellitto; Ana Iglesias-Mejuto; Pasquale del Gaudio; Raquel Costa; Carlos A. García-González; Ana Leite Oliveira

doi:10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b

Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration

Beatriz G. Bernardes
, Clara Sousa
, Maria Rosaria Sellitto
, Ana Iglesias-Mejuto
, Pasquale del Gaudio
, Raquel Costa
, Carlos A. García-González
, Ana Leite Oliveira

Research output: Contribution to conference › Poster

Abstract

The treatment of chronic wounds remains a formidable challenge in regenerative medicine, necessitating multifunctional biomaterials capable of modulating inflammation, promoting angiogenesis, and enabling sustained drug delivery [1]. This study presents a novel class of core–shell aerogel particles engineered from silk fibroin (SF), silk sericin (SS), and alginate (ALG), designed for the controlled release of adenosine (ADO)—a nucleoside with anti-inflammatory and pro-regenerative properties [2]. Using coaxial prilling and supercritical CO₂ drying, two architectures were fabricated: SF/ALG cores enveloped by ALG or ALG/SS shells.

Original language	English
Pages	1-1
Number of pages	1
DOIs	https://doi.org/10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b
Publication status	Published - 23 Jan 2026
Event	5ª Jornada de IBEROS+ - Facultad de Biología - Santiago de Compostela, Santiago de Compostela, Spain Duration: 23 Jan 2026 → 23 Jan 2026

Other

Other	5ª Jornada de IBEROS+
Country/Territory	Spain
City	Santiago de Compostela
Period	23/01/26 → 23/01/26

Access to Document

10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2bLicence: Unspecified

http://hdl.handle.net/10400.14/56814Licence: Unspecified

Embargoed Document

139680656
Final published version, 1.79 MB
Licence: Unspecified
Embargo ends: 23/01/27

5ª Jornada de IBEROS+
Bernardes, B. (Participant), Rosadas, M. (Participant), Oliveira, A. L. (Participant), Rodrigues, F. A. P. (Participant), Pereira, A. B. V. (Participant) & Pazmino Guevara, C. (Participant)
23 Jan 2026
Activity: Participating in or organising an event › Participating in a conference, workshop, ...

1 Finished
2 Active

CBQF - Centre for Biotecnology and Fine Chemistry: UID/50016/2025. Pluriannual 2025-2029
Pintado, M. M. (PI)
1/01/25 → 31/12/29
Project: Research
IBEROS+: Cooperación Transfronteriza de Innovaciones en Aerogeles para Aplicaciones Biomédicas
Oliveira, A. L. (PI)
1/07/23 → 30/06/26
Project: Research
BE@T: Bioeconomia para têxtil e vestuário
Pintado, M. M. (PI), Oliveira-Silva, P. (Researcher), Oliveira, A. L. (Researcher), Vasconcelos, M. (Researcher), Tavaria, F. (Researcher), Couto, J. A. (Researcher), Sousa, C. (Researcher), Costa, E. (Researcher), Bonifácio-Lopes, T. (Research Assistant) & Afonso, T. B. (Researcher)
1/07/22 → 1/07/25
Project: Research

Design and characterization of biopolymer-based core–shell particles for sustained release of adenosine in tissue regeneration
Bernardes, B. G., Sousa, C., Sellitto, M. R., Iglesias-Mejuto, A., Gaudio, P. D., Costa, R., García-González, C. A. & Oliveira, A. L., 23 Jan 2026, p. 1-2. 2 p.
Research output: Contribution to conference › Abstract

Cite this

Bernardes, B. G., Sousa, C., Sellitto, M. R., Iglesias-Mejuto, A., Gaudio, P. D., Costa, R., García-González, C. A., & Oliveira, A. L. (2026). Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration. 1-1. Poster session presented at 5ª Jornada de IBEROS+, Santiago de Compostela, Spain. https://doi.org/10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b

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title = "Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration",

abstract = "The treatment of chronic wounds remains a formidable challenge in regenerative medicine, necessitating multifunctional biomaterials capable of modulating inflammation, promoting angiogenesis, and enabling sustained drug delivery [1]. This study presents a novel class of core–shell aerogel particles engineered from silk fibroin (SF), silk sericin (SS), and alginate (ALG), designed for the controlled release of adenosine (ADO)—a nucleoside with anti-inflammatory and pro-regenerative properties [2]. Using coaxial prilling and supercritical CO₂ drying, two architectures were fabricated: SF/ALG cores enveloped by ALG or ALG/SS shells.",

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doi = "10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b",

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Bernardes, BG , Sousa, C, Sellitto, MR, Iglesias-Mejuto, A, Gaudio, PD, Costa, R, García-González, CA & Oliveira, AL 2026, 'Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration', 5ª Jornada de IBEROS+, Santiago de Compostela, Spain, 23/01/26 - 23/01/26 pp. 1-1. https://doi.org/10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b

TY - CONF

T1 - Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration

AU - Bernardes, Beatriz G.

AU - Sousa, Clara

AU - Sellitto, Maria Rosaria

AU - Iglesias-Mejuto, Ana

AU - Gaudio, Pasquale del

AU - Costa, Raquel

AU - García-González, Carlos A.

AU - Oliveira, Ana Leite

PY - 2026/1/23

Y1 - 2026/1/23

N2 - The treatment of chronic wounds remains a formidable challenge in regenerative medicine, necessitating multifunctional biomaterials capable of modulating inflammation, promoting angiogenesis, and enabling sustained drug delivery [1]. This study presents a novel class of core–shell aerogel particles engineered from silk fibroin (SF), silk sericin (SS), and alginate (ALG), designed for the controlled release of adenosine (ADO)—a nucleoside with anti-inflammatory and pro-regenerative properties [2]. Using coaxial prilling and supercritical CO₂ drying, two architectures were fabricated: SF/ALG cores enveloped by ALG or ALG/SS shells.

AB - The treatment of chronic wounds remains a formidable challenge in regenerative medicine, necessitating multifunctional biomaterials capable of modulating inflammation, promoting angiogenesis, and enabling sustained drug delivery [1]. This study presents a novel class of core–shell aerogel particles engineered from silk fibroin (SF), silk sericin (SS), and alginate (ALG), designed for the controlled release of adenosine (ADO)—a nucleoside with anti-inflammatory and pro-regenerative properties [2]. Using coaxial prilling and supercritical CO₂ drying, two architectures were fabricated: SF/ALG cores enveloped by ALG or ALG/SS shells.

U2 - 10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b

DO - 10.34632/6a2ea2da-ae80-432e-b6d2-2e9f3eadfc2b

M3 - Poster

SP - 1

EP - 1

T2 - 5ª Jornada de IBEROS+

Y2 - 23 January 2026 through 23 January 2026

ER -

Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration

Abstract

Other

Access to Document

Embargoed Document

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Activities

5ª Jornada de IBEROS+

Projects

CBQF - Centre for Biotecnology and Fine Chemistry: UID/50016/2025. Pluriannual 2025-2029

IBEROS+: Cooperación Transfronteriza de Innovaciones en Aerogeles para Aplicaciones Biomédicas

BE@T: Bioeconomia para têxtil e vestuário

Research output

Design and characterization of biopolymer-based core–shell particles for sustained release of adenosine in tissue regeneration

Cite this