Determination of ambroxol in an automated multi-pumping pulsed flow system

João L. M. Santos*, Arnaud Clausse, José L. F. C. Lima, M. L. M. F. S. Saraiva, António O. S. Rangel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


A new flow methodology exploiting the multi-pumping approach was developed for the spectrophotometric determination of ambroxol hydrochloride in pharmaceutical preparations. The flow manifold was implemented by using, exclusively, multiple solenoid-actuated micro-pumps, which acted simultaneously as sample insertion, solutions propelling and reagents commutation units. Linear calibration plots were obtained over an ambroxol concentration ranging from 10 to 200 mg 1 -1 (r.s.d. < 0.5%, n = 15) and a sampling rate of about 60 samples per hour (flow rate = 1.92 ml min -1 , sample volume = 80μl).

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalAnalytical Sciences
Issue number4
Publication statusPublished - Apr 2005


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