TY - JOUR
T1 - Determination of ambroxol in an automated multi-pumping pulsed flow system
AU - Santos, João L. M.
AU - Clausse, Arnaud
AU - Lima, José L. F. C.
AU - Saraiva, M. L. M. F. S.
AU - Rangel, António O. S.
PY - 2005/4
Y1 - 2005/4
N2 - A new flow methodology exploiting the multi-pumping approach was developed for the spectrophotometric determination of ambroxol hydrochloride in pharmaceutical preparations. The flow manifold was implemented by using, exclusively, multiple solenoid-actuated micro-pumps, which acted simultaneously as sample insertion, solutions propelling and reagents commutation units. Linear calibration plots were obtained over an ambroxol concentration ranging from 10 to 200 mg 1 -1 (r.s.d. < 0.5%, n = 15) and a sampling rate of about 60 samples per hour (flow rate = 1.92 ml min -1 , sample volume = 80μl).
AB - A new flow methodology exploiting the multi-pumping approach was developed for the spectrophotometric determination of ambroxol hydrochloride in pharmaceutical preparations. The flow manifold was implemented by using, exclusively, multiple solenoid-actuated micro-pumps, which acted simultaneously as sample insertion, solutions propelling and reagents commutation units. Linear calibration plots were obtained over an ambroxol concentration ranging from 10 to 200 mg 1 -1 (r.s.d. < 0.5%, n = 15) and a sampling rate of about 60 samples per hour (flow rate = 1.92 ml min -1 , sample volume = 80μl).
UR - http://www.scopus.com/inward/record.url?scp=17744374300&partnerID=8YFLogxK
U2 - 10.2116/analsci.21.461
DO - 10.2116/analsci.21.461
M3 - Article
C2 - 15844348
AN - SCOPUS:17744374300
SN - 0910-6340
VL - 21
SP - 461
EP - 464
JO - Analytical Sciences
JF - Analytical Sciences
IS - 4
ER -