Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region

Mário Ribeiro Da Silva; Ruth Maria Dias Ferreira Vinagre; Adenielson Vilar E Silva; Claudia Suellen Ferro De Oliveira; Kemper Nunes Do Santos; Renata Aparecida Andrade Da Costa; Amanda Alves Fecury; Tereza Cristina De Oliveira Corvelo; Juarez Antônio Simões Quaresma; Luisa Caricio Martins

doi:10.1590/0037-8682-1290-2013

Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region

Mário Ribeiro Da Silva, Ruth Maria Dias Ferreira Vinagre, Adenielson Vilar E Silva, Claudia Suellen Ferro De Oliveira, Kemper Nunes Do Santos, Renata Aparecida Andrade Da Costa, Amanda Alves Fecury, Tereza Cristina De Oliveira Corvelo, Juarez Antônio Simões Quaresma, Luisa Caricio Martins^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Introduction: This study compares virulence markers of Helicobacter pylori isolated from patients in 2 cities in the Brazilian Amazon. Methods: The study analyzed 168 patients with chronic gastritis from Belém and 151 from Bragançã, State of Para, Brazil. Levels of bacterial DNA associated with cagA and vacA alleles were checked by PCR, and hematoxylin-eosin staining was used for histologic diagnosis. Results: In Bragançã 87% of patients were genotype slml cogA-positive (slml cagA⁺), compared with 76% in Belém. In samples from patients in both cities, there was an association between slml cagA⁺ strains and gastric mucosal damage. Conclusions: Both cities have a high frequency of slml cagA⁺ strains of H. pylori.

Original language	English
Pages (from-to)	358-361
Number of pages	4
Journal	Revista da Sociedade Brasileira de Medicina Tropical
Volume	46
Issue number	3
DOIs	https://doi.org/10.1590/0037-8682-1290-2013
Publication status	Published - May 2013
Externally published	Yes

Keywords

Cytotoxin-associated
Helicobacter pylori
Vacuolating cytotoxin

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10.1590/0037-8682-1290-2013

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Da Silva, M. R., Dias Ferreira Vinagre, R. M., Vilar E Silva, A., De Oliveira, C. S. F., Do Santos, K. N., Da Costa, R. A. A., Fecury, A. A., De Oliveira Corvelo, T. C., Quaresma, J. A. S., & Martins, L. C. (2013). Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region. Revista da Sociedade Brasileira de Medicina Tropical, 46(3), 358-361. https://doi.org/10.1590/0037-8682-1290-2013

@article{602dae79ab4a4dc09d9270fd492db4bb,

title = "Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region",

abstract = "Introduction: This study compares virulence markers of Helicobacter pylori isolated from patients in 2 cities in the Brazilian Amazon. Methods: The study analyzed 168 patients with chronic gastritis from Bel{\'e}m and 151 from Bragan{\c c}{\~a}, State of Para, Brazil. Levels of bacterial DNA associated with cagA and vacA alleles were checked by PCR, and hematoxylin-eosin staining was used for histologic diagnosis. Results: In Bragan{\c c}{\~a} 87% of patients were genotype slml cogA-positive (slml cagA+), compared with 76% in Bel{\'e}m. In samples from patients in both cities, there was an association between slml cagA+ strains and gastric mucosal damage. Conclusions: Both cities have a high frequency of slml cagA+ strains of H. pylori.",

keywords = "Cytotoxin-associated, Helicobacter pylori, Vacuolating cytotoxin",

author = "{Da Silva}, {M{\'a}rio Ribeiro} and {Dias Ferreira Vinagre}, {Ruth Maria} and {Vilar E Silva}, Adenielson and {De Oliveira}, {Claudia Suellen Ferro} and {Do Santos}, {Kemper Nunes} and {Da Costa}, {Renata Aparecida Andrade} and Fecury, {Amanda Alves} and {De Oliveira Corvelo}, {Tereza Cristina} and Quaresma, {Juarez Ant{\^o}nio Sim{\~o}es} and Martins, {Luisa Caricio}",

year = "2013",

month = may,

doi = "10.1590/0037-8682-1290-2013",

language = "English",

volume = "46",

pages = "358--361",

journal = "Revista da Sociedade Brasileira de Medicina Tropical",

issn = "0037-8682",

publisher = "Sociedade Brasileira de Medicina Tropical",

number = "3",

}

Da Silva, MR, Dias Ferreira Vinagre, RM, Vilar E Silva, A, De Oliveira, CSF, Do Santos, KN, Da Costa, RAA, Fecury, AA, De Oliveira Corvelo, TC, Quaresma, JAS & Martins, LC 2013, 'Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region', Revista da Sociedade Brasileira de Medicina Tropical, vol. 46, no. 3, pp. 358-361. https://doi.org/10.1590/0037-8682-1290-2013

TY - JOUR

T1 - Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region

AU - Da Silva, Mário Ribeiro

AU - Dias Ferreira Vinagre, Ruth Maria

AU - Vilar E Silva, Adenielson

AU - De Oliveira, Claudia Suellen Ferro

AU - Do Santos, Kemper Nunes

AU - Da Costa, Renata Aparecida Andrade

AU - Fecury, Amanda Alves

AU - De Oliveira Corvelo, Tereza Cristina

AU - Quaresma, Juarez Antônio Simões

AU - Martins, Luisa Caricio

PY - 2013/5

Y1 - 2013/5

N2 - Introduction: This study compares virulence markers of Helicobacter pylori isolated from patients in 2 cities in the Brazilian Amazon. Methods: The study analyzed 168 patients with chronic gastritis from Belém and 151 from Bragançã, State of Para, Brazil. Levels of bacterial DNA associated with cagA and vacA alleles were checked by PCR, and hematoxylin-eosin staining was used for histologic diagnosis. Results: In Bragançã 87% of patients were genotype slml cogA-positive (slml cagA+), compared with 76% in Belém. In samples from patients in both cities, there was an association between slml cagA+ strains and gastric mucosal damage. Conclusions: Both cities have a high frequency of slml cagA+ strains of H. pylori.

AB - Introduction: This study compares virulence markers of Helicobacter pylori isolated from patients in 2 cities in the Brazilian Amazon. Methods: The study analyzed 168 patients with chronic gastritis from Belém and 151 from Bragançã, State of Para, Brazil. Levels of bacterial DNA associated with cagA and vacA alleles were checked by PCR, and hematoxylin-eosin staining was used for histologic diagnosis. Results: In Bragançã 87% of patients were genotype slml cogA-positive (slml cagA+), compared with 76% in Belém. In samples from patients in both cities, there was an association between slml cagA+ strains and gastric mucosal damage. Conclusions: Both cities have a high frequency of slml cagA+ strains of H. pylori.

KW - Cytotoxin-associated

KW - Helicobacter pylori

KW - Vacuolating cytotoxin

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U2 - 10.1590/0037-8682-1290-2013

DO - 10.1590/0037-8682-1290-2013

M3 - Article

C2 - 23856857

SN - 0037-8682

VL - 46

SP - 358

EP - 361

JO - Revista da Sociedade Brasileira de Medicina Tropical

JF - Revista da Sociedade Brasileira de Medicina Tropical

IS - 3

ER -

Differences in virulence markers between Helicobacter pylori strains from the Brazilian Amazon region

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Keywords

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