Discovery of novel targets for antivirals: learning from flies

Nelson Martins; Jean Luc Imler; Carine Meignin

doi:10.1016/j.coviro.2016.09.005

Discovery of novel targets for antivirals: learning from flies

Nelson Martins
, Jean Luc Imler
, Carine Meignin

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs to the most diverse group of animals. Genetic and transcriptomic analyses have recently identified Drosophila genes encoding viral restriction factors. Some of them represent evolutionary novelties and their characterization may provide hints for the design of directly acting antivirals. In addition, functional screens revealed conserved host factors required for efficient viral translation, such as the ribosomal protein RACK1 and the release factor Pelo. These proteins are promising candidates for host-targeted antivirals.

Original language	English
Pages (from-to)	64-70
Number of pages	7
Journal	Current Opinion in Virology
Volume	20
DOIs	https://doi.org/10.1016/j.coviro.2016.09.005
Publication status	Published - 1 Oct 2016
Externally published	Yes

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10.1016/j.coviro.2016.09.005

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title = "Discovery of novel targets for antivirals: learning from flies",

abstract = "Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs to the most diverse group of animals. Genetic and transcriptomic analyses have recently identified Drosophila genes encoding viral restriction factors. Some of them represent evolutionary novelties and their characterization may provide hints for the design of directly acting antivirals. In addition, functional screens revealed conserved host factors required for efficient viral translation, such as the ribosomal protein RACK1 and the release factor Pelo. These proteins are promising candidates for host-targeted antivirals.",

author = "Nelson Martins and Imler, \{Jean Luc\} and Carine Meignin",

note = "Funding Information: We thank Franck Martin for the Drosophila 80S 3D model; Jules Hoffmann, Jo{\~a}o Trindade Marques and Evelyne Einhorn for critical reading and comments on the manuscript; European Commission [ H2020-MSCA-IF-2015-705518 ], NIH [ PO1 AI070167 ], ANR [ ANR-13-BSV3-009 ], Infect-ERA [ ANR-14-IFEC-0005 ], Investissements d{\textquoteright}Avenir Programs [ ANR-10-LABX-36 , ANR-11-EQPX-0022 ], and Fondation ARC for funding. Insect images were downloaded from www.shutterstock.com , with an Attribution-ShareAlike license ( http://creativecommons.org/licenses/ ). We apologize to colleagues whose work could not be quoted due to space limitation. Publisher Copyright: {\textcopyright} 2016",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.coviro.2016.09.005",

language = "English",

volume = "20",

pages = "64--70",

journal = "Current Opinion in Virology",

issn = "1879-6257",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Discovery of novel targets for antivirals

T2 - learning from flies

AU - Martins, Nelson

AU - Imler, Jean Luc

AU - Meignin, Carine

N1 - Funding Information: We thank Franck Martin for the Drosophila 80S 3D model; Jules Hoffmann, João Trindade Marques and Evelyne Einhorn for critical reading and comments on the manuscript; European Commission [ H2020-MSCA-IF-2015-705518 ], NIH [ PO1 AI070167 ], ANR [ ANR-13-BSV3-009 ], Infect-ERA [ ANR-14-IFEC-0005 ], Investissements d’Avenir Programs [ ANR-10-LABX-36 , ANR-11-EQPX-0022 ], and Fondation ARC for funding. Insect images were downloaded from www.shutterstock.com , with an Attribution-ShareAlike license ( http://creativecommons.org/licenses/ ). We apologize to colleagues whose work could not be quoted due to space limitation. Publisher Copyright: © 2016

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs to the most diverse group of animals. Genetic and transcriptomic analyses have recently identified Drosophila genes encoding viral restriction factors. Some of them represent evolutionary novelties and their characterization may provide hints for the design of directly acting antivirals. In addition, functional screens revealed conserved host factors required for efficient viral translation, such as the ribosomal protein RACK1 and the release factor Pelo. These proteins are promising candidates for host-targeted antivirals.

AB - Developing antiviral drugs is challenging due to the small number of targets in viruses, and the rapid evolution of viral genes. Animals have evolved a number of efficient antiviral defence mechanisms, which can serve as a source of inspiration for novel therapies. The genetically tractable insect Drosophila belongs to the most diverse group of animals. Genetic and transcriptomic analyses have recently identified Drosophila genes encoding viral restriction factors. Some of them represent evolutionary novelties and their characterization may provide hints for the design of directly acting antivirals. In addition, functional screens revealed conserved host factors required for efficient viral translation, such as the ribosomal protein RACK1 and the release factor Pelo. These proteins are promising candidates for host-targeted antivirals.

UR - https://www.scopus.com/pages/publications/84988447946

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DO - 10.1016/j.coviro.2016.09.005

M3 - Review article

C2 - 27657660

AN - SCOPUS:84988447946

SN - 1879-6257

VL - 20

SP - 64

EP - 70

JO - Current Opinion in Virology

JF - Current Opinion in Virology

ER -

Discovery of novel targets for antivirals: learning from flies

Abstract

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