Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

Neha Raina, Rakesh Pahwa, Jaydeep Bhattacharya, Alok K. Paul, Veeranoot Nissapatorn*, Maria de Lourdes Pereira, Sonia M.R. Oliveira, Karma G. Dolma, Mohammed Rahmatullah, Polrat Wilairatana*, Madhu Gupta*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, along with scale-up translation, are also mentioned in detail. Finally, the potential of the hydrogel in the biomedical sector is discussed, along with its further possibilities for improvement for the development of sophisticated smart hydrogels with pivotal biomedical functions.

Original languageEnglish
Article number574
Number of pages31
JournalPharmaceutics
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 2022
Externally publishedYes

Keywords

  • Biomedical perspectives
  • Clinical trials
  • Contact lenses
  • Drug delivery
  • Hydrogels
  • Therapeutic interventions
  • Tissue engineering
  • Translation
  • Wound management

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