Effect of hydroxyapatite and zinc-containing hydroxyapatite on osseous repair of critical size defect in the rat calvaria

M. Calasans-Maia*, G. V. O. Fernandes, A. Rossi, E. P. Dias, G. D. S. Almeida, F. F. Mitri, J. M. Granjeiro

*Corresponding author for this work

Research output: Contribution to conferencePaperpeer-review

14 Citations (Scopus)

Abstract

Hydroxyapatite (HA), widely used as bone graft, can be modified by the incorporation of bivalent cations (Mg 2- and Zn2+) and its gradual release could favor the bone repair. The purpose of this research was to evaluate the effect of the HA and zinc-containing hydroxyapatite (Zn-HA) in the bone repair in rat calvaria in comparison to autogenous bone. Critical size defect in the calvaria was filled with the graft material and the samples were harvested at the 30, 90 and 180 days. The light microcopy observations showed the biocompatibility of the graft materials. In the Zn-HA group the area of neoformed bone was larger than in the HA group, but smaller than in the autograft. A fibrous connective tissue was more evident around HA granules. It could be conclude that the presence of zinc ions in HA crystal accelerated the osteogenesis and increased the area of newly formed bone in relation to HA.
Original languageEnglish
Pages1273-1276
Number of pages4
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event20th International Symposium on Ceramics in Medicine - Nantes, France
Duration: 24 Oct 200726 Oct 2007
Conference number: 20

Conference

Conference20th International Symposium on Ceramics in Medicine
Country/TerritoryFrance
CityNantes
Period24/10/0726/10/07

Keywords

  • Autograft
  • Bone repair
  • Critical size defect
  • Hydroxyapatite
  • Light microscopy
  • Osteoconduction
  • Rat calvarium
  • Zinc-containing hydroxyapatite

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