TY - JOUR
T1 - Elastin-like polypeptides in development of nanomaterials for application in the medical field
AU - Lima, Letícia Ferreira
AU - Sousa, Mauricio Gonçalves Da Costa
AU - Rodrigues, Gisele Regina
AU - de Oliveira, Kamila Botelho Sampaio
AU - Pereira, Ana Margarida
AU - da Costa, André
AU - Machado, Raul
AU - Franco, Octavio Luiz
AU - Dias, Simoni Campos
N1 - Funding Information:
The authors are grateful to the Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF), the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and the Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT). MR acknowledges FCT I.P. in the scope of the Scientific Employment Stimulus instrument (CEECIND/00526/2018). The authors also acknowledge Fundação para a Ciência e a Tecnologia (FCT I.P., Portugal) under the scope of “Contrato-Programa” UIDB/04050/2020.
Publisher Copyright:
Copyright © 2022 Lima, Sousa, Rodrigues, de Oliveira, Pereira, da Costa, Machado, Franco and Dias.
PY - 2022/4/25
Y1 - 2022/4/25
N2 - Elastin-like polypeptides (ELPs) are biopolymers formed by amino acid sequences derived from tropoelastin. These biomolecules can be soluble below critical temperatures, forming aggregates at higher temperatures, which makes them an interesting source for the design of different nanobiomaterials. These nanobiomaterials can be obtained from heterologous expression in several organisms such as bacteria, fungi, and plants. Thanks to the many advantages of ELPs, they have been used in the biomedical field to develop nanoparticles, nanofibers, and nanocomposites. These nanostructures can be used in multiple applications such as drug delivery systems, treatments of type 2 diabetes, cardiovascular diseases, tissue repair, and cancer therapy. Thus, this review aims to shed some light on the main advances in elastin-like-based nanomaterials, their possible expression forms, and importance to the medical field.
AB - Elastin-like polypeptides (ELPs) are biopolymers formed by amino acid sequences derived from tropoelastin. These biomolecules can be soluble below critical temperatures, forming aggregates at higher temperatures, which makes them an interesting source for the design of different nanobiomaterials. These nanobiomaterials can be obtained from heterologous expression in several organisms such as bacteria, fungi, and plants. Thanks to the many advantages of ELPs, they have been used in the biomedical field to develop nanoparticles, nanofibers, and nanocomposites. These nanostructures can be used in multiple applications such as drug delivery systems, treatments of type 2 diabetes, cardiovascular diseases, tissue repair, and cancer therapy. Thus, this review aims to shed some light on the main advances in elastin-like-based nanomaterials, their possible expression forms, and importance to the medical field.
KW - Biosynthesis
KW - Elastin-like polypeptides
KW - Heterologous expression
KW - Medical field
KW - Nanomaterials
UR - http://www.scopus.com/inward/record.url?scp=85129880662&partnerID=8YFLogxK
U2 - 10.3389/fnano.2022.874790
DO - 10.3389/fnano.2022.874790
M3 - Review article
AN - SCOPUS:85129880662
VL - 4
JO - Frontiers in Nanotechnology
JF - Frontiers in Nanotechnology
SN - 2673-3013
M1 - 874790
ER -
