Elastins-Based Antimicrobial Particles for Delivery of Bioactive Compounds

Raul Machado*, André da Costa, Ana Margarida Pereira, José Carlos Rodriguez-Cabello, Margarida Casal

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

In the development of drug delivery systems, researchers pursue multifunctionality to target more complex problems, while maintaining biocompatibility and high encapsulation efficiency. Herein, we describe the preparation of noncytotoxic particles with intrinsic antimicrobial properties able to entrap bioactive compounds. The particles are composed of a recombinantly produced elastin-like recombinamer functionalized with an antimicrobial peptide, and are spontaneously formed in mild conditions by exploiting the thermoresponsiveness of the elastin-like portion. This chapter provides advice and methods for the preparation of the self-assembled antimicrobial particles, the evaluation of antimicrobial activity and cytotoxicity, and the basis to set up the methodology for the encapsulation of bioactive compounds.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages29-43
Number of pages15
DOIs
Publication statusPublished - 2020
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2118
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Antimicrobial peptide
  • Elastin-like recombinamer
  • Encapsulation
  • Particles
  • Self-assembly

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