Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone microenvironment engineering

Diana Jesus, Ana R. Pinho, Maria C. Gomes, Cláudia S. Oliveira*, João F. Mano

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Bone presents an intrinsic ability for self-regeneration and repair, however critical defects and large fractures require invasive and time-consuming clinical interventions. As an alternative to current therapy, bone tissue engineering (BTE) has primarily aimed to recreate the bone microenvironment by delivering key biomolecules and/or by modification of scaffolds to guide cell fate towards the osteogenic lineage or other phenotypes that may benefit the bone regeneration mechanism. Considering that bone cells communicate, in their native microenvironment, through biochemical and physical signals, most strategies fail when considering only chemical, geometrical or mechanical cues. This is not representative of the physiological conditions, where the cells are simultaneously in contact and stimulated by several cues. Therefore, this review explores the synergistic effect of biochemical/physical cues in regulating cellular events, namely cell adhesion, proliferation, osteogenic differentiation, and mineralization, highlighting the importance of the combined modifications for the development of innovative bone regenerative therapies.
Original languageEnglish
Pages (from-to)3107-3119
Number of pages13
JournalSoft Matter
Volume18
Issue number16
DOIs
Publication statusPublished - 4 Apr 2022
Externally publishedYes

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