Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview

Ana R. Ribeiro, Alexandra S. Maia, Quezia B. Cass, Maria E. Tiritan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed.
Original languageEnglish
Pages (from-to)8-21
Number of pages14
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume968
DOIs
Publication statusPublished - 15 Sep 2014

Keywords

  • Biological matrices
  • Chiral pharmaceuticals
  • Chiral stationary phases
  • Enantioselective chromatography
  • Environmental matrices

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