Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview

Ana R. Ribeiro; Alexandra S. Maia; Quezia B. Cass; Maria E. Tiritan

doi:10.1016/j.jchromb.2014.02.049

Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview

Ana R. Ribeiro
, Alexandra S. Maia
, Quezia B. Cass
, Maria E. Tiritan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed.

Original language	English
Pages (from-to)	8-21
Number of pages	14
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	968
DOIs	https://doi.org/10.1016/j.jchromb.2014.02.049
Publication status	Published - 15 Sept 2014

Keywords

Biological matrices
Chiral pharmaceuticals
Chiral stationary phases
Enantioselective chromatography
Environmental matrices

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10.1016/j.jchromb.2014.02.049

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title = "Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview",

abstract = "This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed.",

keywords = "Biological matrices, Chiral pharmaceuticals, Chiral stationary phases, Enantioselective chromatography, Environmental matrices",

author = "Ribeiro, \{Ana R.\} and Maia, \{Alexandra S.\} and Cass, \{Quezia B.\} and Tiritan, \{Maria E.\}",

note = "Funding Information: This work has been supported by Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia–FCT (PhD grants attributed to Ana Rita Ribeiro, SFRH/BD/64999/2009 and Alexandra Sofia Maia, SFRH/BD/86939/2012, QREN-POPH, European Social Fund and MCTES. This work was also supported by FCT Projects FLUOROPHARMA PTDC/EBB-EBI/111699/2009, PEst-OE/EQB/LA0016/2011 and CEQUIMED PEst-OE/SAU/UI4040/2011. This work was funded also by grant from National Council for Scientific and Technological Development (CNPq). Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2014",

month = sep,

day = "15",

doi = "10.1016/j.jchromb.2014.02.049",

language = "English",

volume = "968",

pages = "8--21",

journal = "Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences",

issn = "1570-0232",

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Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview. / Ribeiro, Ana R.; Maia, Alexandra S.; Cass, Quezia B. et al.
In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Vol. 968, 15.09.2014, p. 8-21.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography

T2 - an overview

AU - Ribeiro, Ana R.

AU - Maia, Alexandra S.

AU - Cass, Quezia B.

AU - Tiritan, Maria E.

N1 - Funding Information: This work has been supported by Fundação para a Ciência e Tecnologia–FCT (PhD grants attributed to Ana Rita Ribeiro, SFRH/BD/64999/2009 and Alexandra Sofia Maia, SFRH/BD/86939/2012, QREN-POPH, European Social Fund and MCTES. This work was also supported by FCT Projects FLUOROPHARMA PTDC/EBB-EBI/111699/2009, PEst-OE/EQB/LA0016/2011 and CEQUIMED PEst-OE/SAU/UI4040/2011. This work was funded also by grant from National Council for Scientific and Technological Development (CNPq). Publisher Copyright: © 2014 Elsevier B.V.. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2014/9/15

Y1 - 2014/9/15

N2 - This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed.

AB - This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed.

KW - Biological matrices

KW - Chiral pharmaceuticals

KW - Chiral stationary phases

KW - Enantioselective chromatography

KW - Environmental matrices

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SN - 1570-0232

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JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

ER -

Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: an overview

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Keywords

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