Enhancement of product selectivity via enzyme immobilization in sequential degradation reactions of polymeric substrates

The balance equations pertaining to the modelling of Greek symbols a slap-shaped bead containing immobilized enzyme uniformly distributed which catalyzes the sequential reactions of degradation of a polymeric substrate were written and analytically solved in dimensionless form. The effect of the Thiele modulus on the selectivity of consumption of each multimeric product was studied for a simple case. Whereas plain diffusional regime leads to lower selectivities than plain kinetic regime, improvements in selectivity of species A(i) relative to species A(i+1), may be obtained at the expense of higher Thiele moduli within a limited range when the diffusivity of A(i) is larger than that of A(i+1), or when the pseudo first order kinetic constant describing the rate of consumption of A(i) is lower than that of A(i+1).