Enhancing bacterial photodynamic inactivation through combined action of potassium iodide and cationic phthalocyanines

Sara R. D. Gamelas; Maria  Bartolomeu; Cátia Vieira; Maria A. F. Faustino; João P. C. Tomé; Augusto C. Tomé; Adelaide Almeida; Leandro M. O. Lourenço

Abstract

Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photosensitizers (PS) in PDI has already proven effectiveness against various microorganisms [4]. Moreover, the addition of KI as a coadjutant can, in certain circumstances, enhance the efficiency of neutral, negative, and positively charged PS against Gram-negative and Gram-positive bacteria [2,4]. In this study will be demonstrated the effect of KI in PDI of E. coli and S. aureus with cationic Pcs bearing tris(trimethylammoniummethyl) or pyridinium-pyrazolyl groups.

Original language	English
Number of pages	1
Publication status	Published - Nov 2023
Event	XXVII Encontro Luso Galego de Química - Centro de Congressos e Exposições da Fundação Dr. António Cupertino de Miranda, Porto, Portugal Duration: 22 Nov 2023 → 24 Nov 2023 https://xxviilgq.events.chemistry.pt/pt

Conference

Conference	XXVII Encontro Luso Galego de Química
Country/Territory	Portugal
City	Porto
Period	22/11/23 → 24/11/23
Internet address	https://xxviilgq.events.chemistry.pt/pt

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93924094Final published version, 110 KBLicence: Unspecified

http://hdl.handle.net/10400.14/46474Licence: Unspecified

CIIS: Center for Interdisciplinary Research in Health
Barros, M. (PI), Rosa, N. (Researcher), Correia, M. J. (Researcher), Caldas, A. C. (Researcher), Amado, J. C. (Researcher), Figueiredo, A. S. (Researcher), Esteves, A. C. (Researcher), Mineiro, A. (Researcher), Abreu, A. M. (Researcher), Duarte, A. S. (Researcher), Almeida, S. F. (Researcher), Correia, A. (Researcher), Moura, A. (Researcher), Almeida, A. (Researcher), Araújo, B. (Researcher), Moura-Netto, C. (Researcher), Ferrito, C. (Researcher), Pais-Vieira, C. (Researcher), Festas, C. (Researcher), Marques-Vieira, C. (Researcher), Catré, D. (Researcher), Nunes, E. (Researcher), Jesus, É. (Researcher), Ribeiro, F. (Researcher), Rosário, F. (Researcher), Fernandes, G. (Researcher), Rato, J. R. (Scholarship holder), Salgado, J. R. (Researcher), Neves-Amado, J. (Researcher), Amendoeira, J. (Researcher), Sá, L. (Researcher), Capelas, M. L. (Researcher), Vieira, M. M. (Researcher), Nunes, M. V. S. (Researcher), Cardoso, M. (Researcher), Veiga, N. J. (Researcher), Fonseca, P. (Researcher), Correia, P. N. (Researcher), Couto, P. (Researcher), Pontífice-Sousa, P. (Researcher), Ravasco, P. (Researcher), Carvalho, P. V. D. (Researcher), Alves, P. (Researcher), Melo, P. (Researcher), Silva, R. (Researcher), Canaipa, R. (Researcher), Noites, R. (Researcher), Rio, R. (Researcher), Almeida, S. (Researcher), Deodato, S. (Researcher), Caldeira, S. (Researcher), Silva, S. (Researcher), Borges, T. (Researcher), Silva, V. (Researcher), Charepe, Z. (Researcher), Rodrigues-Pires, F. (Volunteer), Veludo, F. (Researcher), Carmo, H. (Scholarship holder), Romeiro, J. (Student), Melo, M. (Researcher), Braga, M. (Researcher), Amaral, T. (Researcher), Moreira, M. A. (Researcher), Guerra, N. (Student), Santos, P. (Researcher), Paço, S. (Student), Lynce, S. (Scholarship holder), Miguel, S. (Student), Costa, T. (Researcher), Silva-Neves, V. (Researcher), Silva, A. (Researcher), Carvalho, A. R. (Researcher), Almeida, B. (Researcher), Figueiredo, C. (Researcher), Esteves, E. (Scholarship holder), Araújo, F. M. (Researcher), Garcia, J. G. (Researcher), Santos, L. (Researcher), Santos, N. M. D. (Researcher), Lopes, P. (Researcher), Bornes, R. (Researcher), Silva, R. (Researcher), Costa, S. (Researcher), Silva, S. M. (Researcher), Marques, T. (Researcher), Almeida, A. (Researcher), Santos, M. (Scholarship holder), Santos, P. (Researcher), Miguel, S. (Researcher), Mendes, K. (Researcher), Gomes, A. P. (Researcher), Henriques, J. M. P. (Researcher), Costa, H. A. F. P. (Researcher) & Ribeiro, P. (Researcher)
Fundação para a Ciência e a Tecnologia
1/01/20 → 31/12/24
Project: Research

Cite this

@conference{66f232600bac4a5e881f6fe93614d3ac,

title = "Enhancing bacterial photodynamic inactivation through combined action of potassium iodide and cationic phthalocyanines",

abstract = "Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photosensitizers (PS) in PDI has already proven effectiveness against various microorganisms [4]. Moreover, the addition of KI as a coadjutant can, in certain circumstances, enhance the efficiency of neutral, negative, and positively charged PS against Gram-negative and Gram-positive bacteria [2,4]. In this study will be demonstrated the effect of KI in PDI of E. coli and S. aureus with cationic Pcs bearing tris(trimethylammoniummethyl) or pyridinium-pyrazolyl groups.",

author = "Gamelas, {Sara R. D.} and Maria Bartolomeu and C{\'a}tia Vieira and Faustino, {Maria A. F.} and Tom{\'e}, {Jo{\~a}o P. C.} and Tom{\'e}, {Augusto C.} and Adelaide Almeida and Louren{\c c}o, {Leandro M. O.}",

year = "2023",

month = nov,

language = "English",

note = "XXVII Encontro Luso Galego de Qu{\'i}mica ; Conference date: 22-11-2023 Through 24-11-2023",

url = "https://xxviilgq.events.chemistry.pt/pt",

}

TY - CONF

T1 - Enhancing bacterial photodynamic inactivation through combined action of potassium iodide and cationic phthalocyanines

AU - Gamelas, Sara R. D.

AU - Bartolomeu, Maria

AU - Vieira, Cátia

AU - Faustino, Maria A. F.

AU - Tomé, João P. C.

AU - Tomé, Augusto C.

AU - Almeida, Adelaide

AU - Lourenço, Leandro M. O.

PY - 2023/11

Y1 - 2023/11

N2 - Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photosensitizers (PS) in PDI has already proven effectiveness against various microorganisms [4]. Moreover, the addition of KI as a coadjutant can, in certain circumstances, enhance the efficiency of neutral, negative, and positively charged PS against Gram-negative and Gram-positive bacteria [2,4]. In this study will be demonstrated the effect of KI in PDI of E. coli and S. aureus with cationic Pcs bearing tris(trimethylammoniummethyl) or pyridinium-pyrazolyl groups.

AB - Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photosensitizers (PS) in PDI has already proven effectiveness against various microorganisms [4]. Moreover, the addition of KI as a coadjutant can, in certain circumstances, enhance the efficiency of neutral, negative, and positively charged PS against Gram-negative and Gram-positive bacteria [2,4]. In this study will be demonstrated the effect of KI in PDI of E. coli and S. aureus with cationic Pcs bearing tris(trimethylammoniummethyl) or pyridinium-pyrazolyl groups.

M3 - Abstract

T2 - XXVII Encontro Luso Galego de Química

Y2 - 22 November 2023 through 24 November 2023

ER -

Enhancing bacterial photodynamic inactivation through combined action of potassium iodide and cationic phthalocyanines

Abstract

Conference

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CIIS: Center for Interdisciplinary Research in Health

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