Escherichia coli and Enterococcus faecalis are able to incorporate and enhance a pre-formed Gardnerella vaginalis biofilm

Joana Castro, Daniela Machado, Nuno Cerca

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Gardnerella vaginalis is the most frequent microorganism found in bacterial vaginosis (BV), while Escherichia coli and Enterococcus faecalis are amongst the most frequent pathogens found in urinary tract infections (UTIs). This study aimed to evaluate possible interactions between UTIs pathogens and G. vaginalis using an in vitro dual-species biofilm model. Our results showed that dual-species biofilms reached significantly higher bacterial concentration than monospecies biofilms. Moreover, visualization of dual-populations species in the biofilms, using the epifluorescence microscopy, revealed that all of the urogenital pathogens coexisted with G. vaginalis. In conclusion, our work demonstrates that uropathogens can incorporate into mature BV biofilms.
Original languageEnglish
JournalPathogens and Disease
Volume74
Issue number3
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

Keywords

  • Bacterial vaginosis
  • Mixed biofilms
  • Urinary tract infection
  • Uropathogens

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