Especiação de cobre e zinco em urina - importância dos metais em doenças neurodegenerativas

Maria Fernanda C. Leal; Rita I. L. Catarino; Adriana M. Pimenta; Maria Renata S. Souto; Tatiana S.N. Pinheiro

doi:10.1590/S0100-40422012001000018

Especiação de cobre e zinco em urina - importância dos metais em doenças neurodegenerativas

Translated title of the contribution: Speciation of copper and zinc in urine - importance of metals in neurodegenerative diseases

Maria Fernanda C. Leal^*, Rita I. L. Catarino, Adriana M. Pimenta, Maria Renata S. Souto, Tatiana S.N. Pinheiro

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

6 Downloads

Abstract

Metals such as copper and zinc are essential for the development and maintenance of numerous enzymatic activities, mitochondrial functions, neurotransmission, and also for memorization and learning. However, disruption in their homeostasis can cause neurodegenerative disorders such as the Alzheimer and Parkinson diseases. In this work, the speciation of copper and zinc in urine samples was carried out. To this end, free and total metal concentrations were determined by square wave anodic stripping voltammetry using a glassy carbon electrode coated with bismuth film. The digestion of the samples was performed in a microwave with the addition of oxidant reagents.

Translated title of the contribution	Speciation of copper and zinc in urine - importance of metals in neurodegenerative diseases
Original language	Portuguese
Pages (from-to)	1985-1990
Number of pages	6
Journal	Quimica Nova
Volume	35
Issue number	10
DOIs	https://doi.org/10.1590/S0100-40422012001000018
Publication status	Published - 12 Nov 2012

Keywords

Metals
Neurodegenerative diseases
Stripping voltammetry

Access to Document

10.1590/S0100-40422012001000018Licence: CC BY-NC

37277753Final published version, 703 KBLicence: CC BY-NC

http://hdl.handle.net/10400.14/34220Licence: CC BY-NC

Cite this

@article{c1fbcf7dc8904a4da8616f2b68ca42b9,

title = "Especia{\c c}{\~a}o de cobre e zinco em urina - import{\^a}ncia dos metais em doen{\c c}as neurodegenerativas",

abstract = "Metals such as copper and zinc are essential for the development and maintenance of numerous enzymatic activities, mitochondrial functions, neurotransmission, and also for memorization and learning. However, disruption in their homeostasis can cause neurodegenerative disorders such as the Alzheimer and Parkinson diseases. In this work, the speciation of copper and zinc in urine samples was carried out. To this end, free and total metal concentrations were determined by square wave anodic stripping voltammetry using a glassy carbon electrode coated with bismuth film. The digestion of the samples was performed in a microwave with the addition of oxidant reagents.",

keywords = "Metals, Neurodegenerative diseases, Stripping voltammetry",

author = "Leal, {Maria Fernanda C.} and Catarino, {Rita I. L.} and Pimenta, {Adriana M.} and Souto, {Maria Renata S.} and Pinheiro, {Tatiana S.N.}",

year = "2012",

month = nov,

day = "12",

doi = "10.1590/S0100-40422012001000018",

language = "Portuguese",

volume = "35",

pages = "1985--1990",

journal = "Quimica Nova",

issn = "0100-4042",

publisher = "Sociedade Brasileira de Quimica",

number = "10",

}

TY - JOUR

T1 - Especiação de cobre e zinco em urina - importância dos metais em doenças neurodegenerativas

AU - Leal, Maria Fernanda C.

AU - Catarino, Rita I. L.

AU - Pimenta, Adriana M.

AU - Souto, Maria Renata S.

AU - Pinheiro, Tatiana S.N.

PY - 2012/11/12

Y1 - 2012/11/12

N2 - Metals such as copper and zinc are essential for the development and maintenance of numerous enzymatic activities, mitochondrial functions, neurotransmission, and also for memorization and learning. However, disruption in their homeostasis can cause neurodegenerative disorders such as the Alzheimer and Parkinson diseases. In this work, the speciation of copper and zinc in urine samples was carried out. To this end, free and total metal concentrations were determined by square wave anodic stripping voltammetry using a glassy carbon electrode coated with bismuth film. The digestion of the samples was performed in a microwave with the addition of oxidant reagents.

AB - Metals such as copper and zinc are essential for the development and maintenance of numerous enzymatic activities, mitochondrial functions, neurotransmission, and also for memorization and learning. However, disruption in their homeostasis can cause neurodegenerative disorders such as the Alzheimer and Parkinson diseases. In this work, the speciation of copper and zinc in urine samples was carried out. To this end, free and total metal concentrations were determined by square wave anodic stripping voltammetry using a glassy carbon electrode coated with bismuth film. The digestion of the samples was performed in a microwave with the addition of oxidant reagents.

KW - Metals

KW - Neurodegenerative diseases

KW - Stripping voltammetry

UR - http://www.scopus.com/inward/record.url?scp=84870453643&partnerID=8YFLogxK

U2 - 10.1590/S0100-40422012001000018

DO - 10.1590/S0100-40422012001000018

M3 - Article

AN - SCOPUS:84870453643

SN - 0100-4042

VL - 35

SP - 1985

EP - 1990

JO - Quimica Nova

JF - Quimica Nova

IS - 10

ER -

Especiação de cobre e zinco em urina - importância dos metais em doenças neurodegenerativas

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this