Ethylene oxide sterilization of medical devices: a review

Gisela C.C. Mendes, Teresa R.S. Brandão, Cristina L.M. Silva*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

211 Citations (Scopus)


Ethylene oxide (EO) is a well-known sterilizing agent. However, only recently has its use significantly emerged, based on its range of applications in the field of new medical device development and sterilization. This paper describes the progress in terms of EO sterilization and concludes that it remains a promising field to explore and develop. The EO action mechanism and toxicity are analyzed, and a critical analysis is made on how it is possible to use EO sterilization for medical devices advantageously, with emphasis on cycle design and validation. One huge challenge is related with the development of mathematical models to integrate lethality to allow a continuous increase of process flexibility, without compromising its safety. The scientific community should also focus on other important issues, such as EO diffusion in different substrates, taking into account different environmental conditions both for sterilization and aeration.

Original languageEnglish
Pages (from-to)574-581
Number of pages8
JournalAmerican Journal of Infection Control
Issue number9
Publication statusPublished - Nov 2007


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