Exceptional symmetry profile: a genomic word analysis

Vera Afreixo*, João M. O. S. Rodrigues, Carlos A. C. Bastos, Raquel M. Silva

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The extension of Chargaff’s second rule, also called the DNA symmetry, is pointed as an universal law present in the genomes of species. Previously, a measure of the symmetry above that expected in independence contexts (exceptional symmetry) was proposed to evaluate the phenomenon globally. The global exceptional symmetry was found in several species. However, the analysis of exceptional symmetry by word was not studied in detail. In this work a new exceptional symmetry measure is proposed to evaluate the exceptional symmetry effect by symmetric word pair. We develop a detailed study of the exceptional symmetry by symmetric pairs. We also discuss the exceptional symmetry by symmetric word pair for several organisms: 7 viruses; 5 archaea; 5 bacteria; 14 eukaryotes.
Original languageEnglish
Title of host publication10th International Conference on Practical Applications of Computational Biology and Bioinformatics
EditorsFlorentino Fdez-Riverola, Juan F. De Paz, Miguel P. Rocha, Francisco J. Domínguez Mayo, Mohd Saberi Mohamad
PublisherSpringer Verlag
Pages151-159
Number of pages9
ISBN (Print)9783319401256
DOIs
Publication statusPublished - 2016
Externally publishedYes
EventInternational Conference on Practical Applications of Computational Biology and Bioinformatics PACBB, 2016 - Sevilla, Spain
Duration: 1 Jun 20163 Jun 2016

Publication series

NameAdvances in Intelligent Systems and Computing
Volume477
ISSN (Print)2194-5357

Conference

ConferenceInternational Conference on Practical Applications of Computational Biology and Bioinformatics PACBB, 2016
Country/TerritorySpain
CitySevilla
Period1/06/163/06/16

Keywords

  • Chargaff’s second parity rule
  • Exceptional symmetry
  • Genomic word counts

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