Exploring the bioavailability of phenolic compounds through in vitro simulated gastrointestinal digestion: INFOGEST

Adriana C. S. Pais; Ezequiel R. Coscueta; Maria Manuela Pintado; Armando J. D. Silvestre; Sónia A. O. Santos

Exploring the bioavailability of phenolic compounds through in vitro simulated gastrointestinal digestion: INFOGEST

Adriana C. S. Pais^*
, Ezequiel R. Coscueta
, Maria Manuela Pintado
, Armando J. D. Silvestre
, Sónia A. O. Santos

^*Corresponding author for this work

Research output: Contribution to conference › Poster › peer-review

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Abstract

Conclusions: Studied phenolic compounds did not undergo enzymatic digestion after INFOGEST, as we did not detect any resultant metabolites. Bioaccessibility percentages determined after the intestinal digestion phase showed that most of the studied phenolic compounds were about 50% bioaccessible. Absorption rates of all studied phenolic compounds were high (> 80%), suggesting that they can be absorbed into the systemic circulation or follow to the colon, where gut microbiota may metabolize them. Solubility of phenolic compounds could limit their bioavailability, as QUE and EA, demonstrated lower bioaccessibility along the simulated gastrointestinal tract due to their low solubility in water.

Original language	English
Number of pages	1
Publication status	Published - 2023
Event	XXVIII Encontro Nacional da Sociedade Portuguesa de Química - Universidade de Aveiro, Aveiro, Portugal Duration: 24 Jul 2023 → 26 Jul 2023 https://xxviiienspq.events.chemistry.pt/

Conference

Conference	XXVIII Encontro Nacional da Sociedade Portuguesa de Química
Abbreviated title	ENSPQ 2023
Country/Territory	Portugal
City	Aveiro
Period	24/07/23 → 26/07/23
Internet address	https://xxviiienspq.events.chemistry.pt/

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@conference{29e57f3dd96c4d37bf9e78882a44aaf8,

title = "Exploring the bioavailability of phenolic compounds through in vitro simulated gastrointestinal digestion: INFOGEST",

abstract = "Conclusions: Studied phenolic compounds did not undergo enzymatic digestion after INFOGEST, as we did not detect any resultant metabolites. Bioaccessibility percentages determined after the intestinal digestion phase showed that most of the studied phenolic compounds were about 50\% bioaccessible. Absorption rates of all studied phenolic compounds were high (> 80\%), suggesting that they can be absorbed into the systemic circulation or follow to the colon, where gut microbiota may metabolize them. Solubility of phenolic compounds could limit their bioavailability, as QUE and EA, demonstrated lower bioaccessibility along the simulated gastrointestinal tract due to their low solubility in water.",

author = "Pais, \{Adriana C. S.\} and Coscueta, \{Ezequiel R.\} and Pintado, \{Maria Manuela\} and Silvestre, \{Armando J. D.\} and Santos, \{S{\'o}nia A. O.\}",

year = "2023",

language = "English",

note = "XXVIII Encontro Nacional da Sociedade Portuguesa de Qu{\'i}mica, ENSPQ 2023 ; Conference date: 24-07-2023 Through 26-07-2023",

url = "https://xxviiienspq.events.chemistry.pt/",

}

Exploring the bioavailability of phenolic compounds through in vitro simulated gastrointestinal digestion: INFOGEST. / Pais, Adriana C. S.; Coscueta, Ezequiel R.; Pintado, Maria Manuela et al.
2023. Poster session presented at XXVIII Encontro Nacional da Sociedade Portuguesa de Química, Aveiro, Portugal.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Exploring the bioavailability of phenolic compounds through in vitro simulated gastrointestinal digestion

T2 - XXVIII Encontro Nacional da Sociedade Portuguesa de Química

AU - Pais, Adriana C. S.

AU - Coscueta, Ezequiel R.

AU - Pintado, Maria Manuela

AU - Silvestre, Armando J. D.

AU - Santos, Sónia A. O.

PY - 2023

Y1 - 2023

N2 - Conclusions: Studied phenolic compounds did not undergo enzymatic digestion after INFOGEST, as we did not detect any resultant metabolites. Bioaccessibility percentages determined after the intestinal digestion phase showed that most of the studied phenolic compounds were about 50% bioaccessible. Absorption rates of all studied phenolic compounds were high (> 80%), suggesting that they can be absorbed into the systemic circulation or follow to the colon, where gut microbiota may metabolize them. Solubility of phenolic compounds could limit their bioavailability, as QUE and EA, demonstrated lower bioaccessibility along the simulated gastrointestinal tract due to their low solubility in water.

AB - Conclusions: Studied phenolic compounds did not undergo enzymatic digestion after INFOGEST, as we did not detect any resultant metabolites. Bioaccessibility percentages determined after the intestinal digestion phase showed that most of the studied phenolic compounds were about 50% bioaccessible. Absorption rates of all studied phenolic compounds were high (> 80%), suggesting that they can be absorbed into the systemic circulation or follow to the colon, where gut microbiota may metabolize them. Solubility of phenolic compounds could limit their bioavailability, as QUE and EA, demonstrated lower bioaccessibility along the simulated gastrointestinal tract due to their low solubility in water.

M3 - Poster

Y2 - 24 July 2023 through 26 July 2023

ER -

Exploring the bioavailability of phenolic compounds through in vitro simulated gastrointestinal digestion: INFOGEST

Abstract

Conference

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