Extracellular matrix mimics using hyaluronan-based biomaterials

Sara Amorim; Celso A. Reis; Rui L. Reis; Ricardo A. Pires

doi:10.1016/j.tibtech.2020.06.003

Extracellular matrix mimics using hyaluronan-based biomaterials

Sara Amorim, Celso A. Reis, Rui L. Reis, Ricardo A. Pires^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

112 Citations (Scopus)

Abstract

Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.

Original language	English
Pages (from-to)	90-104
Number of pages	15
Journal	Trends in Biotechnology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.tibtech.2020.06.003
Publication status	Published - Jan 2021
Externally published	Yes

Keywords

Hyaluronan
Extracellular matrix
Hydrogels
Particles
2D surfaces
3D models

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibtech.2020.06.003

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title = "Extracellular matrix mimics using hyaluronan-based biomaterials",

abstract = "Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.",

keywords = "Hyaluronan, Extracellular matrix, Hydrogels, Particles, 2D surfaces, 3D models",

author = "Sara Amorim and Reis, {Celso A.} and Reis, {Rui L.} and Pires, {Ricardo A.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2021",

month = jan,

doi = "10.1016/j.tibtech.2020.06.003",

language = "English",

volume = "39",

pages = "90--104",

journal = "Trends in Biotechnology",

issn = "0167-7799",

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number = "1",

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TY - JOUR

T1 - Extracellular matrix mimics using hyaluronan-based biomaterials

AU - Amorim, Sara

AU - Reis, Celso A.

AU - Reis, Rui L.

AU - Pires, Ricardo A.

PY - 2021/1

Y1 - 2021/1

N2 - Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.

AB - Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.

KW - Hyaluronan

KW - Extracellular matrix

KW - Hydrogels

KW - Particles

KW - 2D surfaces

KW - 3D models

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U2 - 10.1016/j.tibtech.2020.06.003

DO - 10.1016/j.tibtech.2020.06.003

M3 - Review article

C2 - 32654775

SN - 0167-7799

VL - 39

SP - 90

EP - 104

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 1

ER -

Extracellular matrix mimics using hyaluronan-based biomaterials

Abstract

Keywords

UN SDGs

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