Extracorporeal CO2 removal during renal replacement therapy to allow lung-protective ventilation in patients with COVID-19 - associated acute respiratory distress syndrome

Retrospective study on COVID-19 patients undergoing CO2 removal and dialysis (record study), Tomás Lamas

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The aim of this retrospective multicenter observational study is to test the feasibility and safety of a combined extracorporeal CO2 removal (ECCO2R) plus renal replacement therapy (RRT) system to use an ultraprotective ventilator setting while maintaining (1) an effective support of renal function and (2) values of pH within the physiologic limits in a cohort of coronavirus infectious disease 2019 (COVID-19) patients. Among COVID-19 patients admitted to the intensive care unit of 9 participating hospitals, 27 patients with acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI) requiring invasive mechanical ventilation undergoing ECCO2R-plus-RRT treatment were included in the analysis. The treatment allowed to reduce VT from 6.0 ± 0.6 mL/kg at baseline to 4.8 ± 0.8, 4.6 ± 1.0, and 4.3 ± 0.3 mL/kg, driving pressure (ΔP) from 19.8 ± 2.5 cm H2O to 14.8 ± 3.6, 14.38 ± 4.1 and 10.2 ± 1.6 cm H2O after 24 hours, 48 hours, and at discontinuation of ECCO2R-plusRRT (T3), respectively (p < 0.001). PaCO2 and pH remained stable. Plasma creatinine decreased over the study period from 3.30 ± 1.27 to 1.90 ± 1.30 and 1.27 ± 0.90 mg/dL after 24 and 48 hours of treatment, respectively (p < 0.01). No patient-related events associated with the extracorporeal system were reported. These data show that in patients with COVID-19-induced ARDS and AKI, ECCO2R-plus-RRT is effective in allowing ultraprotective ventilator settings while maintaining an effective support of renal function and values of pH within physiologic limits.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalASAIO Journal
Volume69
Issue number1
DOIs
Publication statusPublished - 1 Jan 2023
Externally publishedYes

Keywords

  • COVID-19
  • ECCOR
  • RRT
  • Ultraprotective ventilation

Fingerprint

Dive into the research topics of 'Extracorporeal CO2 removal during renal replacement therapy to allow lung-protective ventilation in patients with COVID-19 - associated acute respiratory distress syndrome'. Together they form a unique fingerprint.

Cite this