TY - JOUR
T1 - Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor
AU - Veiga, Anabela
AU - Castro, Filipa
AU - Ferreira, António
AU - Oliveira, Ana L.
AU - Rocha, Fernando
N1 - Funding Information:
This work was financially supported by: National Funds through FCT (Foundation for Science and Technology) under the project UIDB/50016/2020 of the Centre for Biotechnology and Fine Chemistry - CBQF; and by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by National Funds through FCT/MCTES (PIDDAC). A. Veiga gratefully acknowledges doctoral scholarship [ 2020.08683. BD ] from FCT.
Publisher Copyright:
© 2022 Institution of Chemical Engineers
PY - 2022/7
Y1 - 2022/7
N2 - Several technologies and synthesis routes have been implemented to produce calcium phosphates (CaPs) with distinct characteristics for biomedical applications. However, produce CaPs in a controlled way still represents a challenge. Oscillatory flow reactors (OFRs) are a technology ready to deliver in terms of mixing intensification in multiphase systems. In particular, continuous processes in OFRs improve control over the reaction conditions and can be implemented at an industrial scale. The aim of this work was to study for the first time the influence of the oscillation amplitude (x0: 4, 8 and 18 mm) and frequency (f: 1.9, 4 and 6 Hz) as well as residence time (τ: 3.3, 6.6 min) on the final CaP particles’ physicochemical properties using a continuous precipitation process in a novel modular oscillatory flow plate reactor (MOFPR). Furthermore, other parameters such as the initial reagents concentration, initial Ca/P molar ratio (Ca/P = 1.67, 1.33) and temperature (T = 37, 54 ºC) were also assessed. The synthesized particles and overall process were compared with particles obtained using the same methodology in conventional reactors, evidencing the potential of this technology to fabricate CaPs with tailored properties for potential application as nano or microcarriers for biomedical applications.
AB - Several technologies and synthesis routes have been implemented to produce calcium phosphates (CaPs) with distinct characteristics for biomedical applications. However, produce CaPs in a controlled way still represents a challenge. Oscillatory flow reactors (OFRs) are a technology ready to deliver in terms of mixing intensification in multiphase systems. In particular, continuous processes in OFRs improve control over the reaction conditions and can be implemented at an industrial scale. The aim of this work was to study for the first time the influence of the oscillation amplitude (x0: 4, 8 and 18 mm) and frequency (f: 1.9, 4 and 6 Hz) as well as residence time (τ: 3.3, 6.6 min) on the final CaP particles’ physicochemical properties using a continuous precipitation process in a novel modular oscillatory flow plate reactor (MOFPR). Furthermore, other parameters such as the initial reagents concentration, initial Ca/P molar ratio (Ca/P = 1.67, 1.33) and temperature (T = 37, 54 ºC) were also assessed. The synthesized particles and overall process were compared with particles obtained using the same methodology in conventional reactors, evidencing the potential of this technology to fabricate CaPs with tailored properties for potential application as nano or microcarriers for biomedical applications.
KW - Calcium phosphates
KW - Continuous process
KW - Nano and microcarriers
KW - Oscillatory flow reactors
KW - Precipitation
UR - https://www.scopus.com/pages/publications/85130067254
U2 - 10.1016/j.cherd.2022.04.036
DO - 10.1016/j.cherd.2022.04.036
M3 - Article
AN - SCOPUS:85130067254
SN - 0263-8762
VL - 183
SP - 90
EP - 103
JO - Chemical Engineering Research and Design
JF - Chemical Engineering Research and Design
ER -