Fattymess: fat diet-induced obesity in melanoma metastasis

Joana Correia; Raquel Costa; Cristina Prudêncio; Raquel Soares; Pedro Coelho

doi:10.26537/recipp-23959

Fattymess: fat diet-induced obesity in melanoma metastasis

Joana Correia, Raquel Costa, Cristina Prudêncio, Raquel Soares, Pedro Coelho

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Melanoma is the most aggressive skin cancer characterized by a high metastatic potential and poor survival rate, leading to major morbidity/mortality. Overweight, obesity and diet composition have been identified as risk factors for many types of cancers. However, there are cancers where obesity is associated with favorable outcomes and this has been coined the “obesity paradox”. Preliminary data obtained by our research group disclosed paradoxical findings unveiling that obesity act as a two-edged sword in melanoma: potentiating primary tumor growth, and vascularity/angiogenesis, but at the same time decrease metastatic potential, thus preventing secondary tumor growth. In this exploratory research project, we propose to further explore and deepen the impact that fat-rich diets and obesity partake in melanoma etiology.

Original language	English
Title of host publication	Atas do I Encontro de Investigação da Escola Superior de Saúde do Politécnico do Porto
Editors	Cristina Prudêncio, Nuno Rocha, Manuela Vieira da Silva, Paula Lopes
Publisher	Instituto Politécnico do Porto
Pages	141-148
Number of pages	8
ISBN (Print)	9789899045316
DOIs	https://doi.org/10.26537/recipp-23959
Publication status	Published - 2023
Externally published	Yes

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Correia, J., Costa, R., Prudêncio, C., Soares, R., & Coelho, P. (2023). Fattymess: fat diet-induced obesity in melanoma metastasis. In C. Prudêncio, N. Rocha, M. V. D. Silva, & P. Lopes (Eds.), Atas do I Encontro de Investigação da Escola Superior de Saúde do Politécnico do Porto (pp. 141-148). Instituto Politécnico do Porto. https://doi.org/10.26537/recipp-23959

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title = "Fattymess: fat diet-induced obesity in melanoma metastasis",

abstract = "Melanoma is the most aggressive skin cancer characterized by a high metastatic potential and poor survival rate, leading to major morbidity/mortality. Overweight, obesity and diet composition have been identified as risk factors for many types of cancers. However, there are cancers where obesity is associated with favorable outcomes and this has been coined the “obesity paradox”. Preliminary data obtained by our research group disclosed paradoxical findings unveiling that obesity act as a two-edged sword in melanoma: potentiating primary tumor growth, and vascularity/angiogenesis, but at the same time decrease metastatic potential, thus preventing secondary tumor growth. In this exploratory research project, we propose to further explore and deepen the impact that fat-rich diets and obesity partake in melanoma etiology.",

author = "Joana Correia and Raquel Costa and Cristina Prud{\^e}ncio and Raquel Soares and Pedro Coelho",

year = "2023",

doi = "10.26537/recipp-23959",

language = "English",

isbn = "9789899045316",

pages = "141--148",

editor = "Cristina Prud{\^e}ncio and Nuno Rocha and Silva, {Manuela Vieira da} and Paula Lopes",

booktitle = "Atas do I Encontro de Investiga{\c c}{\~a}o da Escola Superior de Sa{\'u}de do Polit{\'e}cnico do Porto",

publisher = "Instituto Polit{\'e}cnico do Porto",

}

Fattymess: fat diet-induced obesity in melanoma metastasis. / Correia, Joana; Costa, Raquel; Prudêncio, Cristina et al.
Atas do I Encontro de Investigação da Escola Superior de Saúde do Politécnico do Porto. ed. / Cristina Prudêncio; Nuno Rocha; Manuela Vieira da Silva; Paula Lopes. Instituto Politécnico do Porto, 2023. p. 141-148.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Fattymess

T2 - fat diet-induced obesity in melanoma metastasis

AU - Correia, Joana

AU - Costa, Raquel

AU - Prudêncio, Cristina

AU - Soares, Raquel

AU - Coelho, Pedro

PY - 2023

Y1 - 2023

N2 - Melanoma is the most aggressive skin cancer characterized by a high metastatic potential and poor survival rate, leading to major morbidity/mortality. Overweight, obesity and diet composition have been identified as risk factors for many types of cancers. However, there are cancers where obesity is associated with favorable outcomes and this has been coined the “obesity paradox”. Preliminary data obtained by our research group disclosed paradoxical findings unveiling that obesity act as a two-edged sword in melanoma: potentiating primary tumor growth, and vascularity/angiogenesis, but at the same time decrease metastatic potential, thus preventing secondary tumor growth. In this exploratory research project, we propose to further explore and deepen the impact that fat-rich diets and obesity partake in melanoma etiology.

AB - Melanoma is the most aggressive skin cancer characterized by a high metastatic potential and poor survival rate, leading to major morbidity/mortality. Overweight, obesity and diet composition have been identified as risk factors for many types of cancers. However, there are cancers where obesity is associated with favorable outcomes and this has been coined the “obesity paradox”. Preliminary data obtained by our research group disclosed paradoxical findings unveiling that obesity act as a two-edged sword in melanoma: potentiating primary tumor growth, and vascularity/angiogenesis, but at the same time decrease metastatic potential, thus preventing secondary tumor growth. In this exploratory research project, we propose to further explore and deepen the impact that fat-rich diets and obesity partake in melanoma etiology.

U2 - 10.26537/recipp-23959

DO - 10.26537/recipp-23959

M3 - Conference contribution

SN - 9789899045316

SP - 141

EP - 148

BT - Atas do I Encontro de Investigação da Escola Superior de Saúde do Politécnico do Porto

A2 - Prudêncio, Cristina

A2 - Rocha, Nuno

A2 - Silva, Manuela Vieira da

A2 - Lopes, Paula

PB - Instituto Politécnico do Porto

ER -

Fattymess: fat diet-induced obesity in melanoma metastasis

Abstract

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