Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

J. C. Silva*, A. Ponte, M. Mota, R. Pinho, N. Viera, R. Oliveira, Nelson Carvalho, A. C. Gomes, E. Afecto, J. Carvalho

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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Abstract

Background & Aims: Fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing-enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: Case-series study that consecutively included all CPE-carriers that underwent FMT between 2014-2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: Out of 21 CPE-carriers, 8 were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9% (n=10). The median decolonization time was 16-weeks (IQR-23) and ranged from 2-53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
Original languageEnglish
Pages (from-to)925-928
Number of pages4
JournalRevista Espanola de Enfermedades Digestivas
Volume112
Issue number12
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Carbapenamase-producing enterobacteriaceae
  • Decolonization
  • Fecal microbiota transplantation
  • Intestinal carriage
  • Multidrug-resistant infections

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