TY - JOUR
T1 - FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy
AU - Costa-de-Oliveira, Sofia
AU - Miranda, Isabel Marcos
AU - Silva, Raquel M.
AU - Silva, Ana Pinto
AU - Rocha, Rita
AU - Amorim, António
AU - Rodrigues, Acácio Gonçalves
AU - Pina-Vaz, Cidália
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/3
Y1 - 2011/3
N2 - This is the first case report of Candida glabrata-disseminated candidiasis describing the acquisition of echinocandin resistance following anidulafungin treatment. The initial isolates recovered were susceptible to echinocandins. However, during 27 days of anidulafungin treatment, two resistant strains were isolated (from the blood and peritoneal fluid). The resistant peritoneal fluid isolate exhibited a Ser663Pro mutation in position 1987 of FKS2 HS1 (hot spot 1), whereas the resistant blood isolate displayed a phenylalanine deletion (Phe659).
AB - This is the first case report of Candida glabrata-disseminated candidiasis describing the acquisition of echinocandin resistance following anidulafungin treatment. The initial isolates recovered were susceptible to echinocandins. However, during 27 days of anidulafungin treatment, two resistant strains were isolated (from the blood and peritoneal fluid). The resistant peritoneal fluid isolate exhibited a Ser663Pro mutation in position 1987 of FKS2 HS1 (hot spot 1), whereas the resistant blood isolate displayed a phenylalanine deletion (Phe659).
UR - http://www.scopus.com/inward/record.url?scp=79952357849&partnerID=8YFLogxK
U2 - 10.1128/AAC.00589-10
DO - 10.1128/AAC.00589-10
M3 - Article
C2 - 21149621
AN - SCOPUS:79952357849
SN - 0066-4804
VL - 55
SP - 1312
EP - 1314
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 3
ER -