TY - JOUR
T1 - Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles
T2 - an innovative approach for UV skin protection
AU - Andreani, T.
AU - Dias-Ferreira, J.
AU - Fangueiro, J. F.
AU - Souza, A. L.R.
AU - Kiill, C. P.
AU - Gremião, M. P.D.
AU - García, M. L.
AU - Silva, A. M.
AU - Souto, E. B.
N1 - Funding Information:
This work was supported by the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE), co-financed by FEDER , under the Partnership Agreement PT2020 through the projects M-ERA-NET/0004/2015-PAIRED and UIDB/04469/2020 (granted to Eliana B. Souto) and UID/AGR/04033/2019 (granted to Amélia M. Silva).
Publisher Copyright:
© 2020
PY - 2020/5
Y1 - 2020/5
N2 - Sunscreens have been employed on daily skin care for centuries. Their role in protecting the skin from sun damage, avoiding accelerated photoaging and even limiting the risk of development of skin cancer is unquestionable. Although several chemical and physical filters are approved as sunscreens for human use, their safety profile is dependent on their concentration in the formulation which governs their acceptance by the regulatory agencies. A strategic delivery of such molecules should provide a UV protection and limit the skin penetration. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) may offer an alternative approach to achieve a synergistic effect on the UV protection when loaded with sunscreens as particles themselves also have a UV light scattering effect. Besides, the lipid character of SLN and NLC improves the encapsulation of lipophilic compounds, with enhanced loading capacity. Silica nanoparticles have also been employed in sunscreen formulations. Due to the formed sol-gel complexes, which covalently entrap sunscreen molecules, a controlled release is also achieved. In the present work, we have developed a new sunscreen formulation composed of hybrid SLN-Silica particles loaded with octyl methoxycinnamate (Parsol®MCX), and their further incorporation into a hydrogel for skin administration. Hybrid SLN-silica particles of 210.0 ± 3.341 nm of mean size, polydispersity below 0.3, zeta potential of ca. |7| mV, loading capacity of 19.9% and encapsulation efficiency of 98.3% have been produced. Despite the slight negative surface charge, the developed hybrid nanoparticles remained physicochemically stable over the study period. Turbiscan transmission profiles confirmed the colloidal stability of the formulations under stress conditions. The texture profile analysis of Parsol-SLN and Parsol-SLN-Si revealed semi-solid properties (e.g. adhesiveness, hardness, cohesiveness, springiness, gumminess, chewiness, resilience) suitable for topical application, together with the bioadhesiveness in the skin of pig ears. The non-irritation profile of the hybrid nanoparticles before and after dispersion into Carbopol hydrogels was confirmed by HET-CAM test.
AB - Sunscreens have been employed on daily skin care for centuries. Their role in protecting the skin from sun damage, avoiding accelerated photoaging and even limiting the risk of development of skin cancer is unquestionable. Although several chemical and physical filters are approved as sunscreens for human use, their safety profile is dependent on their concentration in the formulation which governs their acceptance by the regulatory agencies. A strategic delivery of such molecules should provide a UV protection and limit the skin penetration. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) may offer an alternative approach to achieve a synergistic effect on the UV protection when loaded with sunscreens as particles themselves also have a UV light scattering effect. Besides, the lipid character of SLN and NLC improves the encapsulation of lipophilic compounds, with enhanced loading capacity. Silica nanoparticles have also been employed in sunscreen formulations. Due to the formed sol-gel complexes, which covalently entrap sunscreen molecules, a controlled release is also achieved. In the present work, we have developed a new sunscreen formulation composed of hybrid SLN-Silica particles loaded with octyl methoxycinnamate (Parsol®MCX), and their further incorporation into a hydrogel for skin administration. Hybrid SLN-silica particles of 210.0 ± 3.341 nm of mean size, polydispersity below 0.3, zeta potential of ca. |7| mV, loading capacity of 19.9% and encapsulation efficiency of 98.3% have been produced. Despite the slight negative surface charge, the developed hybrid nanoparticles remained physicochemically stable over the study period. Turbiscan transmission profiles confirmed the colloidal stability of the formulations under stress conditions. The texture profile analysis of Parsol-SLN and Parsol-SLN-Si revealed semi-solid properties (e.g. adhesiveness, hardness, cohesiveness, springiness, gumminess, chewiness, resilience) suitable for topical application, together with the bioadhesiveness in the skin of pig ears. The non-irritation profile of the hybrid nanoparticles before and after dispersion into Carbopol hydrogels was confirmed by HET-CAM test.
KW - Hydrogel
KW - Nanotechnology
KW - Octyl methoxycinnamate
KW - Pharmaceutical chemistry
KW - Pharmaceutical science
KW - Silica hybrid nanoparticles
KW - SLN
KW - Solid lipid nanoparticles
KW - Sunscreens
UR - http://www.scopus.com/inward/record.url?scp=85084091815&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2020.e03831
DO - 10.1016/j.heliyon.2020.e03831
M3 - Article
C2 - 32395645
AN - SCOPUS:85084091815
SN - 2405-8440
VL - 6
JO - Heliyon
JF - Heliyon
IS - 5
M1 - e03831
ER -
