From remodeling to quiescence: the transformation of the vascular network

Marie Ouarné, Andreia Pena, Cláudio Areias Franco*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

The vascular system is essential for embryogenesis, healing, and homeostasis. Dysfunction or deregulated blood vessel function contributes to multiple diseases, including diabetic retinopathy, cancer, hypertension, or vascular malformations. A balance between the formation of new blood vessels, vascular remodeling, and vessel quiescence is fundamental for tissue growth and function. Whilst the major mechanisms contributing to the formation of new blood vessels have been well explored in recent years, vascular remodeling and quiescence remain poorly understood. In this review, we highlight the cellular and molecular mechanisms responsible for vessel remodeling and quiescence during angiogenesis. We further underline how impaired remodeling and/or destabilization of vessel networks can contribute to vascular pathologies. Finally, we speculate how addressing the molecular mechanisms of vascular remodeling and stabilization could help to treat vascular-related disorders.
Original languageEnglish
Article number203735
JournalCells and Development
Volume168
DOIs
Publication statusPublished - Dec 2021
Externally publishedYes

Keywords

  • Angiogenesis
  • Endothelial cell
  • Vascular disease
  • Vascular quiescence
  • Vascular remodeling

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