From the outside, from within: biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia

Mariana L. Oliveira, Padma Akkapeddi, Isabel Alcobia, Afonso R. Almeida, Bruno A. Cardoso, Rita Fragoso, Teresa L. Serafim, João T. Barata

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer that arises from clonal expansion of transformed T-cell precursors. In this review we summarize the current knowledge on the external stimuli and cell-intrinsic lesions that drive aberrant activation of pivotal, pro-tumoral intracellular signaling pathways in T-cell precursors, driving transformation, leukemia expansion, spread or resistance to therapy. In addition to their pathophysiological relevance, receptors and kinases involved in signal transduction are often attractive candidates for targeted drug development. As such, we discuss also the potential of T-ALL signaling players as targets for therapeutic intervention.
Original languageEnglish
Pages (from-to)10-25
Number of pages16
JournalCellular Signalling
Volume38
DOIs
Publication statusPublished - Oct 2017
Externally publishedYes

Keywords

  • Genetics
  • Interleukin-7 receptor
  • Microenvironment
  • Notch
  • Signaling therapies
  • T-cell acute lymphoblastic leukemia

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