@inbook{bfe59ba68ccb4a71b1fdc956b1686032,
title = "Fundamentals on osteochondral tissue engineering",
abstract = "The repair and regeneration of osteochondral (OC) defects has been increasing owing the high number of diseases, trauma and injuries. Although current clinical options are effective for the treatment of the OC lesions, new therapeutic options are necessary for the complete regeneration of the damaged articular cartilage which has a limited healing capacity. OC tissue engineering has been proposing advanced tools and technologies involving structured scaffolds, bioactive molecules, and cells for the repair and regeneration of the bone and cartilage tissues, as well as their interface. Multi-phased or stratified scaffolds with distinct bone and cartilage sections have been designed for OC repair. Diverse forms, as porous scaffolds, fibres, and hydrogels are the most commonly strategies used for OC tissue engineering. This chapter presents the current treatment and biomimetic strategies for OC tissue engineering. Structure and properties of the OC tissue are also briefly described.",
keywords = "Amorphous calcium phosphate, Articular cartilage, Collagen fibril, Composite scaffold, Subchondral bone",
author = "Viviana Ribeiro and Sandra Pina and Oliveira, {Joaquim Miguel} and Reis, {Rui Lu{\'i}s}",
note = "Funding Information: Acknowledgments The research leading to this work has received funding from the European Union{\textquoteright}s Seventh Framework Program (FP7/2007-2013) under grant Agreement No REGPOT-CT2012-316331-POLARIS, and from QREN (ON.2—NORTE-01-0124-FEDER-000016) cofinanced by North Portugal Regional Operational Program (ON.2—O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). Thanks are also due to the Portuguese Foundation for Science and Technology (FCT) and FSE/POCH (Fundo Social Europeu atrave{\'s} do Programa Operacional do Capital Humano), PD/59/2013, for the project PEst-C/SAU/LA0026/201, for the fellowship grants of Sandra Pina (SFRH/BPD/108763/2015) and Viviana Ribeiro (PD/BD/113806/2015), and for the distinction attributed to J.M. Oliveira under the Investigator FCT program (IF/00423/2012). Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",
year = "2017",
doi = "10.1007/978-3-319-44785-8_7",
language = "English",
isbn = "9783319447834",
series = "Studies in Mechanobiology, Tissue Engineering and Biomaterials",
publisher = "Springer",
pages = "129--146",
editor = "Oliveira, {Joaquim Miguel} and Reis, {Rui Lu{\'i}s}",
booktitle = "Regenerative strategies for the treatment of knee joint disabilities",
address = "Germany",
}