Gastrointestinal delivery of codfish skin-derived collagen hydrolysates: deep eutectic solvent extraction and bioactivity analysis

Isa Silva, Bárbara M. C. Vaz, Sérgio Sousa, Maria Manuela Pintado, Ezequiel R. Coscueta*, Sónia P. M. Ventura

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
30 Downloads

Abstract

The fishing industry produces substantial by-products, such as heads, skins, bones, and scales, rich in collagen—a prevalent protein in these materials. However, further application of deep eutectic solvent-based extraction remains unexplored. In this study, we extracted collagen with urea: propanoic acid mixture (U:PA; 1:2) with a 2.2% yield, followed by enzymatic hydrolysis with alcalase for 120 min. The resulting bioactive peptides demonstrated notable antioxidant activity (961 µmol TE) and antihypertensive properties (39.3% ACE inhibition). Subsequently, we encapsulated 39.3% of these hydrolysates in chitosan-TPP capsules, which released about 58% of their content, primarily in the intestine, as mimicked in the in vitro model of the gastrointestinal tract. Although the digestion process did not significantly alter the size of the non-encapsulated collagen peptides, it did influence their health benefits. The promising results suggest that further research could optimize the use of collagen from fish by-products, potentially offering a sustainable source for health products.
Original languageEnglish
Article number113729
Number of pages26
JournalFood research international
Volume175
DOIs
Publication statusPublished - 1 Jan 2024

Keywords

  • Codfish skin
  • Deep eutectic solvents
  • Marine collagen
  • Bioactive peptides
  • Colon delivery
  • Fishery byproducts
  • Nutraceutical release
  • Atlantic codfish
  • Gadus morhua

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