TY - JOUR
T1 - Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil
AU - Faria, Nuno R.
AU - Da Costa, Antonio Charlys
AU - Lourenço, José
AU - Loureiro, Paula
AU - Lopes, Maria Esther
AU - Ribeiro, Roberto
AU - Alencar, Cecilia Salete
AU - Kraemer, Moritz U.G.
AU - Villabona-Arenas, Christian J.
AU - Wu, Chieh Hsi
AU - Thézé, Julien
AU - Khan, Kamran
AU - Brent, Shannon E.
AU - Romano, Camila
AU - Delwart, Eric
AU - Custer, Brian
AU - Busch, Michael P.
AU - Pybus, Oliver G.
AU - Sabino, Ester C.
AU - Neto, Cesar De Almeida
AU - Mendrone-Junior, Alfredo
AU - Bárbara Carneiro-Proietti, Anna
AU - Sampaio, Divaldo De Almeida
AU - Lobo, Clarisse
AU - Capuani, Ligia
AU - Ferreira, João Eduardo
AU - Oikawa, Marcio
AU - Losco Takecian, Pedro
AU - Oliveira, Cláudia Di Lorenzo
AU - Kelly, Shannon
AU - Gonçalez, Thelma T.
AU - Brambilla, Donald
AU - McClure, Christopher
AU - Glynn, Simone A.
N1 - Funding Information:
N.R.F. is funded by a Sir Henry Dale Fellowship (grant 204311/Z/16/Z). ACC is funded by FAPESP #2012/03417-8, 2014/03417-7 and 2017/00021-9. JL received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 268904 – DIVERSITY. MUGK is supported by the Society in Science, The Branco Weiss Fellowship, administered by the ETH Zurich and acknowledges funding from a Training Grant from the National Institute of Child Health and Human Development (T32HD040128) and the National Library of Medicine of the National Institutes of Health (R01LM010812, R01LM011965). We thank Shirley Cavalcante Vasconcelos Komninakis (UNIFESP), Luciano Monteiro da Silva and Lucy Santos Vilas Boas, (IMT-USP) and Paulo Brito, director from SEOMA/RJ, for daily meteorological data from Rio de Janeiro municipality. This work was funded by FAPESP # 2016/01735-2 and 2011/18955-1, and the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/European Research Council grant agreement number 614725-PATHPHYLODYN.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naïve populations. By analysing 92 newly generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue virus serotype 4 during the 2012 outbreak in Rio de Janeiro. Phylogenetic analysis indicates that the outbreak was caused by genotype II, although two isolates of genotype I were also detected for the first time in Rio de Janeiro. Evolutionary analysis and modelling estimates are congruent, indicating a reproduction number above 1 between January and June, and at least two thirds of infections being unnoticed. Modelling analysis suggests that viral transmission started in early January, which is consistent with multiple introductions, most likely from the northern states of Brazil, and with an increase in within-country air travel to Rio de Janeiro. The combination of genetic and epidemiological data from blood donor banks may be useful to anticipate epidemic spread of arboviruses.
AB - Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naïve populations. By analysing 92 newly generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue virus serotype 4 during the 2012 outbreak in Rio de Janeiro. Phylogenetic analysis indicates that the outbreak was caused by genotype II, although two isolates of genotype I were also detected for the first time in Rio de Janeiro. Evolutionary analysis and modelling estimates are congruent, indicating a reproduction number above 1 between January and June, and at least two thirds of infections being unnoticed. Modelling analysis suggests that viral transmission started in early January, which is consistent with multiple introductions, most likely from the northern states of Brazil, and with an increase in within-country air travel to Rio de Janeiro. The combination of genetic and epidemiological data from blood donor banks may be useful to anticipate epidemic spread of arboviruses.
UR - http://www.scopus.com/inward/record.url?scp=85033666008&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-15152-8
DO - 10.1038/s41598-017-15152-8
M3 - Article
C2 - 29123142
AN - SCOPUS:85033666008
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 15216
ER -
