Genomic and epidemiological monitoring of yellow fever virus transmission potential

N. R. Faria; M. U.G. Kraemer; S. C. Hill; J. Goes De Jesus; R. S. Aguiar; F. C. M. Iani; J. Xavier; J. Quick; L. Du Plessis; S. Dellicour; J. Thézé; R. D. O. Carvalho; G. Baele; C. H. Wu; P. P. Silveira; M. B. Arruda; M. A. Pereira; G. C. Pereira; J. Lourenço; U. Obolski; L. Abade; T. I. Vasylyeva; M. Giovanetti; D. Yi; D. J. Weiss; G. R.W. Wint; F. M. Shearer; S. Funk; B. Nikolay; V. Fonseca; T. E.R. Adelino; M. A.A. Oliveira; M. V.F. Silva; L. Sacchetto; P. O. Figueiredo; I. M. Rezende; E. M. Mello; R. F.C. Said; D. A. Santos; M. L. Ferraz; M. G. Brito; L. F. Santana; M. T. Menezes; R. M. Brindeiro; A. Tanuri; M. S. Cunha; J. S. Nogueira; M. C.L. Mendonça; M. H.O. Garcia; A. L. Abreu

doi:10.1126/science.aat7115

Genomic and epidemiological monitoring of yellow fever virus transmission potential

N. R. Faria^*
, M. U.G. Kraemer
, S. C. Hill
, J. Goes De Jesus
, R. S. Aguiar
, F. C. M. Iani
, J. Xavier
, J. Quick
, L. Du Plessis
, S. Dellicour
, J. Thézé
, R. D. O. Carvalho
, G. Baele
, C. H. Wu
, P. P. Silveira
, M. B. Arruda
, M. A. Pereira
, G. C. Pereira
, J. Lourenço
, U. Obolski

L. Abade, T. I. Vasylyeva, M. Giovanetti, D. Yi, D. J. Weiss, G. R.W. Wint, F. M. Shearer, S. Funk, B. Nikolay, V. Fonseca, T. E.R. Adelino, M. A.A. Oliveira, M. V.F. Silva, L. Sacchetto, P. O. Figueiredo, I. M. Rezende, E. M. Mello, R. F.C. Said, D. A. Santos, M. L. Ferraz, M. G. Brito, L. F. Santana, M. T. Menezes, R. M. Brindeiro, A. Tanuri, M. S. Cunha, J. S. Nogueira, M. C.L. Mendonça, M. H.O. Garcia, A. L. Abreu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

272 Citations (Scopus)

Abstract

The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.

Original language	English
Pages (from-to)	894-899
Number of pages	6
Journal	Science
Volume	361
Issue number	6405
DOIs	https://doi.org/10.1126/science.aat7115
Publication status	Published - 31 Aug 2018
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Faria, N. R., Kraemer, M. U. G., Hill, S. C., De Jesus, J. G., Aguiar, R. S., Iani, F. C. M., Xavier, J., Quick, J., Du Plessis, L., Dellicour, S., Thézé, J., Carvalho, R. D. O., Baele, G., Wu, C. H., Silveira, P. P., Arruda, M. B., Pereira, M. A., Pereira, G. C., Lourenço, J., ... Abreu, A. L. (2018). Genomic and epidemiological monitoring of yellow fever virus transmission potential. Science, 361(6405), 894-899. https://doi.org/10.1126/science.aat7115

@article{dafde698cc554157b33e417064c4b438,

title = "Genomic and epidemiological monitoring of yellow fever virus transmission potential",

abstract = "The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.",

author = "Faria, \{N. R.\} and Kraemer, \{M. U.G.\} and Hill, \{S. C.\} and \{De Jesus\}, \{J. Goes\} and Aguiar, \{R. S.\} and Iani, \{F. C. M.\} and J. Xavier and J. Quick and \{Du Plessis\}, L. and S. Dellicour and J. Th{\'e}z{\'e} and Carvalho, \{R. D. O.\} and G. Baele and Wu, \{C. H.\} and Silveira, \{P. P.\} and Arruda, \{M. B.\} and Pereira, \{M. A.\} and Pereira, \{G. C.\} and J. Louren{\c c}o and U. Obolski and L. Abade and Vasylyeva, \{T. I.\} and M. Giovanetti and D. Yi and Weiss, \{D. J.\} and Wint, \{G. R.W.\} and Shearer, \{F. M.\} and S. Funk and B. Nikolay and V. Fonseca and Adelino, \{T. E.R.\} and Oliveira, \{M. A.A.\} and Silva, \{M. V.F.\} and L. Sacchetto and Figueiredo, \{P. O.\} and Rezende, \{I. M.\} and Mello, \{E. M.\} and Said, \{R. F.C.\} and Santos, \{D. A.\} and Ferraz, \{M. L.\} and Brito, \{M. G.\} and Santana, \{L. F.\} and Menezes, \{M. T.\} and Brindeiro, \{R. M.\} and A. Tanuri and Cunha, \{M. S.\} and Nogueira, \{J. S.\} and Mendon{\c c}a, \{M. C.L.\} and Garcia, \{M. H.O.\} and Abreu, \{A. L.\}",

note = "Publisher Copyright: 2017 {\textcopyright} The Authors,",

year = "2018",

month = aug,

day = "31",

doi = "10.1126/science.aat7115",

language = "English",

volume = "361",

pages = "894--899",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6405",

}

Faria, NR, Kraemer, MUG, Hill, SC, De Jesus, JG, Aguiar, RS, Iani, FCM, Xavier, J, Quick, J, Du Plessis, L, Dellicour, S, Thézé, J, Carvalho, RDO, Baele, G, Wu, CH, Silveira, PP, Arruda, MB, Pereira, MA, Pereira, GC, Lourenço, J, Obolski, U, Abade, L, Vasylyeva, TI, Giovanetti, M, Yi, D, Weiss, DJ, Wint, GRW, Shearer, FM, Funk, S, Nikolay, B, Fonseca, V, Adelino, TER, Oliveira, MAA, Silva, MVF, Sacchetto, L, Figueiredo, PO, Rezende, IM, Mello, EM, Said, RFC, Santos, DA, Ferraz, ML, Brito, MG, Santana, LF, Menezes, MT, Brindeiro, RM, Tanuri, A, Cunha, MS, Nogueira, JS, Mendonça, MCL, Garcia, MHO & Abreu, AL 2018, 'Genomic and epidemiological monitoring of yellow fever virus transmission potential', Science, vol. 361, no. 6405, pp. 894-899. https://doi.org/10.1126/science.aat7115

TY - JOUR

T1 - Genomic and epidemiological monitoring of yellow fever virus transmission potential

AU - Faria, N. R.

AU - Kraemer, M. U.G.

AU - Hill, S. C.

AU - De Jesus, J. Goes

AU - Aguiar, R. S.

AU - Iani, F. C. M.

AU - Xavier, J.

AU - Quick, J.

AU - Du Plessis, L.

AU - Dellicour, S.

AU - Thézé, J.

AU - Carvalho, R. D. O.

AU - Baele, G.

AU - Wu, C. H.

AU - Silveira, P. P.

AU - Arruda, M. B.

AU - Pereira, M. A.

AU - Pereira, G. C.

AU - Lourenço, J.

AU - Obolski, U.

AU - Abade, L.

AU - Vasylyeva, T. I.

AU - Giovanetti, M.

AU - Yi, D.

AU - Weiss, D. J.

AU - Wint, G. R.W.

AU - Shearer, F. M.

AU - Funk, S.

AU - Nikolay, B.

AU - Fonseca, V.

AU - Adelino, T. E.R.

AU - Oliveira, M. A.A.

AU - Silva, M. V.F.

AU - Sacchetto, L.

AU - Figueiredo, P. O.

AU - Rezende, I. M.

AU - Mello, E. M.

AU - Said, R. F.C.

AU - Santos, D. A.

AU - Ferraz, M. L.

AU - Brito, M. G.

AU - Santana, L. F.

AU - Menezes, M. T.

AU - Brindeiro, R. M.

AU - Tanuri, A.

AU - Cunha, M. S.

AU - Nogueira, J. S.

AU - Mendonça, M. C.L.

AU - Garcia, M. H.O.

AU - Abreu, A. L.

PY - 2018/8/31

Y1 - 2018/8/31

N2 - The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.

AB - The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.

UR - https://www.scopus.com/pages/publications/85052626601

U2 - 10.1126/science.aat7115

DO - 10.1126/science.aat7115

M3 - Article

C2 - 30139911

AN - SCOPUS:85052626601

SN - 0036-8075

VL - 361

SP - 894

EP - 899

JO - Science

JF - Science

IS - 6405

ER -

Genomic and epidemiological monitoring of yellow fever virus transmission potential

Abstract

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