Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay

Noelia Morel; Marta Giovanetti; Vagner Fonseca; Analía Burgueño; Mauricio Lima; Emerson Castro; Natália R. Guimarães; Felipe C. M. Iani; Victoria Bormida; Maria Noel Cortinas; Viviana Ramas; Leticia Coppola; Ana I. Bento; Alexander Rosewell; Leticia Franco; Jairo Mendez Rico; José Lourenço; Luiz Carlos Junior Alcantara; Hector Chiparelli

doi:10.1016/j.heliyon.2024.e39246

Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay

Noelia Morel, Marta Giovanetti^*, Vagner Fonseca, Analía Burgueño, Mauricio Lima, Emerson Castro, Natália R. Guimarães, Felipe C. M. Iani, Victoria Bormida, Maria Noel Cortinas, Viviana Ramas, Leticia Coppola, Ana I. Bento, Alexander Rosewell, Leticia Franco, Jairo Mendez Rico, José Lourenço, Luiz Carlos Junior Alcantara^*, Hector Chiparelli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Downloads

Abstract

This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.

Original language	English
Article number	e39246
Number of pages	4
Journal	Heliyon
Volume	10
Issue number	22
DOIs	https://doi.org/10.1016/j.heliyon.2024.e39246
Publication status	Published - 30 Nov 2024

Keywords

Dengue virus
Genomic monitoring
South America
Uruguay

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.heliyon.2024.e39246Licence: CC BY-NC-ND

108924578Final published version, 343 KBLicence: CC BY-NC-ND

http://hdl.handle.net/10400.14/47243Licence: CC BY-NC-ND

Cite this

Morel, N., Giovanetti, M., Fonseca, V., Burgueño, A., Lima, M., Castro, E., Guimarães, N. R., Iani, F. C. M., Bormida, V., Cortinas, M. N., Ramas, V., Coppola, L., Bento, A. I., Rosewell, A., Franco, L., Rico, J. M., Lourenço, J., Alcantara, L. C. J., & Chiparelli, H. (2024). Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay. Heliyon, 10(22), Article e39246. https://doi.org/10.1016/j.heliyon.2024.e39246

@article{5ff656c2fc2d4f319a4d4c74e0df38d4,

title = "Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay",

abstract = "This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.",

keywords = "Dengue virus, Genomic monitoring, South America, Uruguay",

author = "Noelia Morel and Marta Giovanetti and Vagner Fonseca and Anal{\'i}a Burgue{\~n}o and Mauricio Lima and Emerson Castro and Guimar{\~a}es, {Nat{\'a}lia R.} and Iani, {Felipe C. M.} and Victoria Bormida and Cortinas, {Maria Noel} and Viviana Ramas and Leticia Coppola and Bento, {Ana I.} and Alexander Rosewell and Leticia Franco and Rico, {Jairo Mendez} and Jos{\'e} Louren{\c c}o and Alcantara, {Luiz Carlos Junior} and Hector Chiparelli",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = nov,

day = "30",

doi = "10.1016/j.heliyon.2024.e39246",

language = "English",

volume = "10",

journal = "Heliyon",

issn = "2405-8440",

publisher = "Elsevier Ltd.",

number = "22",

}

Morel, N, Giovanetti, M, Fonseca, V, Burgueño, A, Lima, M, Castro, E, Guimarães, NR, Iani, FCM, Bormida, V, Cortinas, MN, Ramas, V, Coppola, L, Bento, AI, Rosewell, A, Franco, L, Rico, JM, Lourenço, J, Alcantara, LCJ & Chiparelli, H 2024, 'Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay', Heliyon, vol. 10, no. 22, e39246. https://doi.org/10.1016/j.heliyon.2024.e39246

TY - JOUR

T1 - Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay

AU - Morel, Noelia

AU - Giovanetti, Marta

AU - Fonseca, Vagner

AU - Burgueño, Analía

AU - Lima, Mauricio

AU - Castro, Emerson

AU - Guimarães, Natália R.

AU - Iani, Felipe C. M.

AU - Bormida, Victoria

AU - Cortinas, Maria Noel

AU - Ramas, Viviana

AU - Coppola, Leticia

AU - Bento, Ana I.

AU - Rosewell, Alexander

AU - Franco, Leticia

AU - Rico, Jairo Mendez

AU - Lourenço, José

AU - Alcantara, Luiz Carlos Junior

AU - Chiparelli, Hector

PY - 2024/11/30

Y1 - 2024/11/30

N2 - This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.

AB - This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.

KW - Dengue virus

KW - Genomic monitoring

KW - South America

KW - Uruguay

UR - http://www.scopus.com/inward/record.url?scp=85208454734&partnerID=8YFLogxK

U2 - 10.1016/j.heliyon.2024.e39246

DO - 10.1016/j.heliyon.2024.e39246

M3 - Article

AN - SCOPUS:85208454734

SN - 2405-8440

VL - 10

JO - Heliyon

JF - Heliyon

IS - 22

M1 - e39246

ER -

Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this