HBV X protein: Elucidating a role in oncogenesis

Mark A. Feitelson; Helena M.G.P.V. Reis; Jingbo Pan; Marcy Clayton; Bill Sun; N. Lale Satiroglu-Tufan; Zhaorui Lian

doi:10.2217/17460794.3.5.455

HBV X protein: Elucidating a role in oncogenesis

Mark A. Feitelson^*
, Helena M.G.P.V. Reis
, Jingbo Pan
, Marcy Clayton
, Bill Sun
, N. Lale Satiroglu-Tufan
, Zhaorui Lian

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Chronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxA9 contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC.

Original language	English
Pages (from-to)	455-470
Number of pages	16
Journal	Future Virology
Volume	3
Issue number	5
DOIs	https://doi.org/10.2217/17460794.3.5.455
Publication status	Published - Sept 2008
Externally published	Yes

Keywords

Apoptosis
Fibrosis
Hepatitis B x antigen
Hepatocellular carcinoma
Senescence
Signal transduction
Steatosis
Treatment
Tumor suppressors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/17460794.3.5.455

Cite this

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title = "HBV X protein: Elucidating a role in oncogenesis",

abstract = "Chronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxA9 contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC.",

keywords = "Apoptosis, Fibrosis, Hepatitis B x antigen, Hepatocellular carcinoma, Senescence, Signal transduction, Steatosis, Treatment, Tumor suppressors",

author = "Feitelson, \{Mark A.\} and Reis, \{Helena M.G.P.V.\} and Jingbo Pan and Marcy Clayton and Bill Sun and Satiroglu-Tufan, \{N. Lale\} and Zhaorui Lian",

year = "2008",

month = sep,

doi = "10.2217/17460794.3.5.455",

language = "English",

volume = "3",

pages = "455--470",

journal = "Future Virology",

issn = "1746-0794",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - HBV X protein

T2 - Elucidating a role in oncogenesis

AU - Feitelson, Mark A.

AU - Reis, Helena M.G.P.V.

AU - Pan, Jingbo

AU - Clayton, Marcy

AU - Sun, Bill

AU - Satiroglu-Tufan, N. Lale

AU - Lian, Zhaorui

PY - 2008/9

Y1 - 2008/9

N2 - Chronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxA9 contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC.

AB - Chronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxA9 contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC.

KW - Apoptosis

KW - Fibrosis

KW - Hepatitis B x antigen

KW - Hepatocellular carcinoma

KW - Senescence

KW - Signal transduction

KW - Steatosis

KW - Treatment

KW - Tumor suppressors

UR - https://www.scopus.com/pages/publications/55849132680

U2 - 10.2217/17460794.3.5.455

DO - 10.2217/17460794.3.5.455

M3 - Review article

AN - SCOPUS:55849132680

SN - 1746-0794

VL - 3

SP - 455

EP - 470

JO - Future Virology

JF - Future Virology

IS - 5

ER -

HBV X protein: Elucidating a role in oncogenesis

Abstract

Keywords

UN SDGs

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