Hesperidin from orange peel as a promising skincare bioactive: an overview

Cristina V. Rodrigues, Manuela Pintado*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review



The pursuit for better skin health, driven by collective and individual perceptions, has led to the demand for sustainable skincare products. Environmental factors and lifestyle choices can accelerate skin aging, causing issues like inflammation, wrinkles, elasticity loss, hyperpigmentation, and dryness. The skincare industry is innovating to meet consumers’ requests for cleaner and natural options. Simultaneously, environmental issues concerning waste generation have been leading to sustainable strategies based on the circular economy. A noteworthy solution consists of citrus by-product valorization, as such by-products can be used as a source of bioactive molecules. Citrus processing, particularly, generates substantial waste amounts (around 50% of the whole fruit), causing unprecedented environmental burdens. Hesperidin, a flavonoid abundant in orange peels, is considered to hold immense potential for clean skin health product applications due to its antioxidant, anti-inflammatory, and anticarcinogenic properties. This review explores hesperidin extraction and purification methodologies as well as key skincare application areas: (i) antiaging and skin barrier enhancement, (ii) UV radiation-induced damage, (iii) hyperpigmentation and depigmentation conditions, (iv) wound healing, and (v) skin cancer and other cutaneous diseases. This work’s novelty lies in the comprehensive coverage of hesperidin’s promising skincare applications while also demonstrating its potential as a sustainable ingredient from a circular economy approach.

Original languageEnglish
Article number1890
Number of pages31
JournalInternational Journal of Molecular Sciences
Issue number3
Publication statusPublished - 4 Feb 2024


  • Food industry byproducts
  • Hesperidin
  • Orange peels
  • Renewable bioactive compounds
  • Sustainable skincare formulations


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