Hydroxyapatite-based materials of marine origin: a bioactivity and sintering study

C. Piccirillo; R. C. Pullar; E. Costa; A. Santos-Silva; M. M. E. Pintado; P. M. L. Castro

doi:10.1016/j.msec.2015.03.020

Hydroxyapatite-based materials of marine origin: a bioactivity and sintering study

C. Piccirillo, R. C. Pullar, E. Costa, A. Santos-Silva, M. M. E. Pintado, P. M. L. Castro^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.

Original language	English
Pages (from-to)	309-315
Number of pages	7
Journal	Materials Science and Engineering C
Volume	51
DOIs	https://doi.org/10.1016/j.msec.2015.03.020
Publication status	Published - 1 Jun 2015

Keywords

Bioactivity
Haemolysis
Hydroxyapatite
Sintering

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10.1016/j.msec.2015.03.020

http://hdl.handle.net/10400.14/19931

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title = "Hydroxyapatite-based materials of marine origin: a bioactivity and sintering study",

abstract = "Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.",

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T2 - a bioactivity and sintering study

AU - Piccirillo, C.

AU - Pullar, R. C.

AU - Costa, E.

AU - Santos-Silva, A.

AU - Pintado, M. M. E.

AU - Castro, P. M. L.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.

AB - Single phase hydroxyapatite (HAp) and biphasic material hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) were obtained from a marine source (Atlantic cod fish bones). Here we report a study on the biological properties of these materials, including cytotoxicity, bioactivity and haemocompatibility. Results showed that the materials are not cytotoxic, neither in their powder nor in pellet form; indeed growth of Saos-2 cells was comparable to that of commercial. The haemolysis rate was lower than 2%; hence the materials can be classified as non-haemolytic. Moreover, when immersed in Simulated Body Fluid (SBF), crystal formation was observed on the surface of both materials. The sintering behaviour of the samples was also studied; both powders showed very high sinterability (density higher than 95% of the theoretical value). Overall, these results confirm the suitability of these materials for biomedical applications.

KW - Bioactivity

KW - Haemolysis

KW - Hydroxyapatite

KW - Sintering

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ER -

Hydroxyapatite-based materials of marine origin: a bioactivity and sintering study

Abstract

Keywords

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