TY - GEN
T1 - Identification of DNA CpG islands using inter-dinucleotide distances
AU - Afreixo, Vera
AU - Bastos, Carlos A. C.
AU - Rodrigues, João M. O. S.
AU - Silva, Raquel M.
N1 - Funding Information:
This work was supported by Portuguese funds through the CIDMA - Center for Research and Development in Mathematics and Applications, IEETA - Institute of Electronics and Telematics Engineering of Aveiro and the Portuguese Foundation for Science and Technology (“FCT–Fundação para a Ciência e a Tecnologia”), within projects PEst-OE/MAT/UI4106/2014 and PEst-OE/EEI/UI0127/2014. RMS is supported by the project Neuropath (CENTRO-07-ST24-FEDER-002034), co-funded by QREN “Mais Centro” program and the EU.
Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - In this study we set to explore the potentialities of the inter-genomic symbols distance for finding CpG islands in DNA sequences. We explore the distance distributions of the inter CpG and SS distance in the independent nucleotide context (reference). We confront the empirical results from the complete human genome, CpG islands and non CpG islands, with the corresponding reference results. We propose a model to discriminate CpG islands based on some statistical properties of the inter-dinucleotide distances distributions in DNA sequences. The results of this exploratory study suggest that inter-SS symbols distance has high ability to discriminate CpG islands.
AB - In this study we set to explore the potentialities of the inter-genomic symbols distance for finding CpG islands in DNA sequences. We explore the distance distributions of the inter CpG and SS distance in the independent nucleotide context (reference). We confront the empirical results from the complete human genome, CpG islands and non CpG islands, with the corresponding reference results. We propose a model to discriminate CpG islands based on some statistical properties of the inter-dinucleotide distances distributions in DNA sequences. The results of this exploratory study suggest that inter-SS symbols distance has high ability to discriminate CpG islands.
UR - http://www.scopus.com/inward/record.url?scp=84937510862&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-20352-2_11
DO - 10.1007/978-3-319-20352-2_11
M3 - Conference contribution
AN - SCOPUS:84937510862
T3 - Communications in Computer and Information Science
SP - 162
EP - 172
BT - Optimization in the Natural Sciences - 30th Euro Mini-Conference, EmC-ONS 2014, Revised Selected Papers
A2 - Plakhov, Alexander
A2 - Tchemisova, Tatiana
A2 - Freitas, Adelaide
PB - Springer Verlag
T2 - 30th EURO Mini-conference on Optimization in the Natural Sciences, EmC-ONS 2014
Y2 - 5 February 2015 through 9 February 2015
ER -