Identification of DNA CpG islands using inter-dinucleotide distances

Vera Afreixo*, Carlos A. C. Bastos, João M. O. S. Rodrigues, Raquel M. Silva

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)


In this study we set to explore the potentialities of the inter-genomic symbols distance for finding CpG islands in DNA sequences. We explore the distance distributions of the inter CpG and SS distance in the independent nucleotide context (reference). We confront the empirical results from the complete human genome, CpG islands and non CpG islands, with the corresponding reference results. We propose a model to discriminate CpG islands based on some statistical properties of the inter-dinucleotide distances distributions in DNA sequences. The results of this exploratory study suggest that inter-SS symbols distance has high ability to discriminate CpG islands.
Original languageEnglish
Title of host publicationOptimization in the Natural Sciences - 30th Euro Mini-Conference, EmC-ONS 2014, Revised Selected Papers
EditorsAlexander Plakhov, Tatiana Tchemisova, Adelaide Freitas
PublisherSpringer Verlag
Number of pages11
ISBN (Electronic)9783319203515
Publication statusPublished - 2015
Externally publishedYes
Event30th EURO Mini-conference on Optimization in the Natural Sciences, EmC-ONS 2014 - Aveiro, Portugal
Duration: 5 Feb 20159 Feb 2015

Publication series

NameCommunications in Computer and Information Science
ISSN (Print)1865-0929


Conference30th EURO Mini-conference on Optimization in the Natural Sciences, EmC-ONS 2014


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