Immunopathology and parasite sequestration cause severe cerebral trypanosomiasis in animals

Sara Silva Pereira, Mariana De Niz, Karine Serre, Marie Ouarné, Claudio A. Franco, Luisa M. Figueiredo*

*Corresponding author for this work

Research output: Working paperPreprint

Abstract

Trypanosoma congolense causes a syndrome of variable severity in animals in sub-Saharan Africa.Cerebral trypanosomiasis is an acute form, but the mechanism underlying this severity remains unknown. We developed a mouse model of cerebral trypanosomiasis with T. congolense strain 1/148 and characterized the cellular, behavioral and physiological consequences of this infection. Using invivo imaging, we show large parasite sequestration in the brain vasculature for long periods of time (upto 8 hours), that results in extensive brain damage partly caused by ICAM1 - mediated recruitment and accumulation of T cells. Antibody-mediated ICAM1 blocking and lymphocyte absence reduce parasite sequestration in the brain and prevent the onset of cerebral trypanosomiasis. Here, we establish a new mouse model of cerebral trypanosomiasis and we propose a mechanism whereby parasite sequestration,host ICAM1, and T cells play a pivotal role.
Original languageEnglish
Pages1-39
Number of pages39
DOIs
Publication statusPublished - 5 Nov 2021
Externally publishedYes

Publication series

NameResearch Square
ISSN (Print)2693-5015

Keywords

  • Cerebral trypanosomiasis
  • Sequestration
  • Trypanosoma congolense
  • Animal African trypanosomiasis
  • Disease severity
  • Immunopathology

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