Impact of phlorotannin extracts from fucus vesiculosus on human gut microbiota

Marcelo D. Catarino; Catarina Marçal; Teresa Bonifácio-Lopes; Débora Campos; Nuno Mateus; Artur M. S. Silva; Maria Manuela Pintado; Susana M. Cardoso

doi:10.3390/md19070375

Impact of phlorotannin extracts from fucus vesiculosus on human gut microbiota

Marcelo D. Catarino, Catarina Marçal, Teresa Bonifácio-Lopes, Débora Campos, Nuno Mateus, Artur M. S. Silva, Maria Manuela Pintado, Susana M. Cardoso^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

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Abstract

Recent studies indicate that plant polyphenols could be pointed as potential prebiotic candidates since they may interact with the gut microbiota, stimulating its growth and the production of metabolites. However, little is known about the fate of brown seaweeds’ phlorotannins during their passage throughout the gastrointestinal tract. This work aimed to evaluate the stability and bioaccessibility of Fucus vesiculosus phlorotannins after being submitted to a simulated digestive process, as well as their possible modulatory effects on gut microbiota and short-chain fatty acids production following a fermentation procedure using fecal inoculates to mimic the conditions of the large intestine. The stability of phlorotannins throughout the gastrointestinal tract was reduced, with a bioaccessibility index between 2 and 14%. Moreover, slight alterations in the growth of certain commensal bacteria were noticed, with Enterococcus spp. being the most enhanced group. Likewise, F. vesiculosus phlorotannins displayed striking capacity to enhance the levels of propionate and butyrate, which are two important short-chain fatty acids known for their role in intestinal homeostasis. In summary, this work provides valuable information regarding the behavior of F. vesiculosus phlorotannins along the gastrointestinal tract, presenting clear evidence that these compounds can positively contribute to the maintenance of a healthy gastrointestinal condition.

Original language	English
Article number	375
Number of pages	17
Journal	Marine Drugs
Volume	19
Issue number	7
DOIs	https://doi.org/10.3390/md19070375
Publication status	Published - 29 Jun 2021

Keywords

Bioaccessibility
Brown seaweeds
Gastrointestinal tract
Gut microbiota
Phlorotannins
Prebiotics
Short-chain fatty acids

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10.3390/md19070375Licence: CC BY

37326401Final published version, 1.3 MBLicence: CC BY

http://hdl.handle.net/10400.14/34209Licence: CC BY

Cite this

@article{dc14a7e5d9e94e80ad43549f988ca88c,

title = "Impact of phlorotannin extracts from fucus vesiculosus on human gut microbiota",

abstract = "Recent studies indicate that plant polyphenols could be pointed as potential prebiotic candidates since they may interact with the gut microbiota, stimulating its growth and the production of metabolites. However, little is known about the fate of brown seaweeds{\textquoteright} phlorotannins during their passage throughout the gastrointestinal tract. This work aimed to evaluate the stability and bioaccessibility of Fucus vesiculosus phlorotannins after being submitted to a simulated digestive process, as well as their possible modulatory effects on gut microbiota and short-chain fatty acids production following a fermentation procedure using fecal inoculates to mimic the conditions of the large intestine. The stability of phlorotannins throughout the gastrointestinal tract was reduced, with a bioaccessibility index between 2 and 14%. Moreover, slight alterations in the growth of certain commensal bacteria were noticed, with Enterococcus spp. being the most enhanced group. Likewise, F. vesiculosus phlorotannins displayed striking capacity to enhance the levels of propionate and butyrate, which are two important short-chain fatty acids known for their role in intestinal homeostasis. In summary, this work provides valuable information regarding the behavior of F. vesiculosus phlorotannins along the gastrointestinal tract, presenting clear evidence that these compounds can positively contribute to the maintenance of a healthy gastrointestinal condition.",

keywords = "Bioaccessibility, Brown seaweeds, Gastrointestinal tract, Gut microbiota, Phlorotannins, Prebiotics, Short-chain fatty acids",

author = "Catarino, {Marcelo D.} and Catarina Mar{\c c}al and Teresa Bonif{\'a}cio-Lopes and D{\'e}bora Campos and Nuno Mateus and Silva, {Artur M. S.} and Pintado, {Maria Manuela} and Cardoso, {Susana M.}",

note = "Funding Information: Thanks to the University of Aveiro (UA) and the Science and Technology Founda-tion/Ministry of Education and Science (FCT/MEC) for funding the Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) (UIDB/50006/2020), through national funds and, where applicable, co-financed by FEDER, within Portugal 2020. We would like to thank the scientific collaboration under the FCT project UID/Multi/50016/2019. Marcelo D. Catarino{\textquoteright}s PhD grant (PD/BD/114577/2016) was funded by the FCT.This research was funded by the European Union (FEDER funds through COMPETE POCI-01-0145-FEDER-031015) and national funds (FCT, Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia) through project PTDC/BAA-AGR/31015/2017, “Algaphlor—brown algae phlorotannins: from bioavailability to the development of new functional foods”. Funding Information: Acknowledgments: Thanks to the University of Aveiro (UA) and the Science and Technology Foundation/Ministry of Education and Science (FCT/MEC) for funding the Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) (UIDB/50006/2020), through national funds and, where applicable, co-financed by FEDER, within Portugal 2020. We would like to thank the scientific collaboration under the FCT project UID/Multi/50016/2019. Marcelo D. Catarino{\textquoteright}s PhD grant (PD/BD/114577/2016) was funded by the FCT. Funding Information: Funding: This research was funded by the European Union (FEDER funds through COMPETE POCI-01-0145-FEDER-031015) and national funds (FCT, Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia) through project PTDC/BAA-AGR/31015/2017, “Algaphlor—brown algae phlorotannins: from bioavailability to the development of new functional foods”. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

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doi = "10.3390/md19070375",

language = "English",

volume = "19",

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T1 - Impact of phlorotannin extracts from fucus vesiculosus on human gut microbiota

AU - Catarino, Marcelo D.

AU - Marçal, Catarina

AU - Bonifácio-Lopes, Teresa

AU - Campos, Débora

AU - Mateus, Nuno

AU - Silva, Artur M. S.

AU - Pintado, Maria Manuela

AU - Cardoso, Susana M.

N1 - Funding Information: Thanks to the University of Aveiro (UA) and the Science and Technology Founda-tion/Ministry of Education and Science (FCT/MEC) for funding the Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) (UIDB/50006/2020), through national funds and, where applicable, co-financed by FEDER, within Portugal 2020. We would like to thank the scientific collaboration under the FCT project UID/Multi/50016/2019. Marcelo D. Catarino’s PhD grant (PD/BD/114577/2016) was funded by the FCT.This research was funded by the European Union (FEDER funds through COMPETE POCI-01-0145-FEDER-031015) and national funds (FCT, Fundação para a Ciência e Tecnologia) through project PTDC/BAA-AGR/31015/2017, “Algaphlor—brown algae phlorotannins: from bioavailability to the development of new functional foods”. Funding Information: Acknowledgments: Thanks to the University of Aveiro (UA) and the Science and Technology Foundation/Ministry of Education and Science (FCT/MEC) for funding the Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) (UIDB/50006/2020), through national funds and, where applicable, co-financed by FEDER, within Portugal 2020. We would like to thank the scientific collaboration under the FCT project UID/Multi/50016/2019. Marcelo D. Catarino’s PhD grant (PD/BD/114577/2016) was funded by the FCT. Funding Information: Funding: This research was funded by the European Union (FEDER funds through COMPETE POCI-01-0145-FEDER-031015) and national funds (FCT, Fundação para a Ciência e Tecnologia) through project PTDC/BAA-AGR/31015/2017, “Algaphlor—brown algae phlorotannins: from bioavailability to the development of new functional foods”. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6/29

Y1 - 2021/6/29

N2 - Recent studies indicate that plant polyphenols could be pointed as potential prebiotic candidates since they may interact with the gut microbiota, stimulating its growth and the production of metabolites. However, little is known about the fate of brown seaweeds’ phlorotannins during their passage throughout the gastrointestinal tract. This work aimed to evaluate the stability and bioaccessibility of Fucus vesiculosus phlorotannins after being submitted to a simulated digestive process, as well as their possible modulatory effects on gut microbiota and short-chain fatty acids production following a fermentation procedure using fecal inoculates to mimic the conditions of the large intestine. The stability of phlorotannins throughout the gastrointestinal tract was reduced, with a bioaccessibility index between 2 and 14%. Moreover, slight alterations in the growth of certain commensal bacteria were noticed, with Enterococcus spp. being the most enhanced group. Likewise, F. vesiculosus phlorotannins displayed striking capacity to enhance the levels of propionate and butyrate, which are two important short-chain fatty acids known for their role in intestinal homeostasis. In summary, this work provides valuable information regarding the behavior of F. vesiculosus phlorotannins along the gastrointestinal tract, presenting clear evidence that these compounds can positively contribute to the maintenance of a healthy gastrointestinal condition.

AB - Recent studies indicate that plant polyphenols could be pointed as potential prebiotic candidates since they may interact with the gut microbiota, stimulating its growth and the production of metabolites. However, little is known about the fate of brown seaweeds’ phlorotannins during their passage throughout the gastrointestinal tract. This work aimed to evaluate the stability and bioaccessibility of Fucus vesiculosus phlorotannins after being submitted to a simulated digestive process, as well as their possible modulatory effects on gut microbiota and short-chain fatty acids production following a fermentation procedure using fecal inoculates to mimic the conditions of the large intestine. The stability of phlorotannins throughout the gastrointestinal tract was reduced, with a bioaccessibility index between 2 and 14%. Moreover, slight alterations in the growth of certain commensal bacteria were noticed, with Enterococcus spp. being the most enhanced group. Likewise, F. vesiculosus phlorotannins displayed striking capacity to enhance the levels of propionate and butyrate, which are two important short-chain fatty acids known for their role in intestinal homeostasis. In summary, this work provides valuable information regarding the behavior of F. vesiculosus phlorotannins along the gastrointestinal tract, presenting clear evidence that these compounds can positively contribute to the maintenance of a healthy gastrointestinal condition.

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KW - Brown seaweeds

KW - Gastrointestinal tract

KW - Gut microbiota

KW - Phlorotannins

KW - Prebiotics

KW - Short-chain fatty acids

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SN - 1660-3397

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JO - Marine Drugs

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ER -

Impact of phlorotannin extracts from fucus vesiculosus on human gut microbiota

Abstract

Keywords

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CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

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Impact of phlorotannin extracts from fucus vesiculosus on human gut microbiota

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

Cite this