Impact of simulated in vitro gastrointestinal digestion on bioactive compounds, bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder

Ricardo Gómez-García; Ana A. Vilas-Boas; Manuela Machado; Débora A. Campos; Cristóbal N. Aguilar; Ana R. Madureira; Manuela Pintado

doi:10.1016/j.fbio.2022.101726

Impact of simulated in vitro gastrointestinal digestion on bioactive compounds, bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder

Ricardo Gómez-García, Ana A. Vilas-Boas, Manuela Machado, Débora A. Campos, Cristóbal N. Aguilar, Ana R. Madureira, Manuela Pintado^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products, considering (i) the recovery and accessibility indexes, (ii) the changes on antioxidant activity, and (iii) the prebiotic effect. Throughout exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were observed. However, these both parameters exhibited stable accessibility, accounting with 81.89%, 76.55%, and 54.07% for TPC, ABTS and DPPH, respectively. After gastrointestinal digestion, the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and Lactobacillus strains, possibly associated with the high content of simple sugar (glucose and fructose). This fraction also showed to be safe on Caco-2 intestinal cells. These findings suggest that MPJ might be used as a potential food functional ingredient.

Original language	English
Article number	101726
Number of pages	10
Journal	Food Bioscience
Volume	47
DOIs	https://doi.org/10.1016/j.fbio.2022.101726
Publication status	Published - Jun 2022

Keywords

Functional ingredients
Melon by-products
Phenolic antioxidants
Prebiotic effect
Simulated digestion

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10.1016/j.fbio.2022.101726

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@article{41d583be762b41239524dfc16ce74e12,

title = "Impact of simulated in vitro gastrointestinal digestion on bioactive compounds, bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder",

abstract = "The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products, considering (i) the recovery and accessibility indexes, (ii) the changes on antioxidant activity, and (iii) the prebiotic effect. Throughout exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were observed. However, these both parameters exhibited stable accessibility, accounting with 81.89%, 76.55%, and 54.07% for TPC, ABTS and DPPH, respectively. After gastrointestinal digestion, the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and Lactobacillus strains, possibly associated with the high content of simple sugar (glucose and fructose). This fraction also showed to be safe on Caco-2 intestinal cells. These findings suggest that MPJ might be used as a potential food functional ingredient.",

keywords = "Functional ingredients, Melon by-products, Phenolic antioxidants, Prebiotic effect, Simulated digestion",

author = "Ricardo G{\'o}mez-Garc{\'i}a and Vilas-Boas, {Ana A.} and Manuela Machado and Campos, {D{\'e}bora A.} and Aguilar, {Crist{\'o}bal N.} and Madureira, {Ana R.} and Manuela Pintado",

note = "Funding Information: The authors would like to thank the National Council of Science and Technology (CONACyT, Mexico) for PhD fellowship support granted to G{\'o}mez-Garc{\'i}a Ricardo and also the authors would like to thank to the project MultiBiorefinery: Estrat{\'e}gias multiuso para a valoriza{\c c}{\~a}o de uma gama alargada de subprodutos agroflorestais e das pescas: Um passo em frente na cria{\c c}{\~a}o de uma biorrefinaria{"} financiado pelo Programa Operacional Competitividade e Internacionaliza{\c c}{\~a}o (POCI-01-0145-FEDER-016403) e pelo Programa Operacional Regional de Lisboa (LISBOA-01-0145-FEDER-016403), na sua componente FEDER e pela Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia, I.P. na componente nacional (SAICTPAC/0040/2015). Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = jun,

doi = "10.1016/j.fbio.2022.101726",

language = "English",

volume = "47",

journal = "Food Bioscience",

issn = "2212-4292",

publisher = "Elsevier",

}

Impact of simulated in vitro gastrointestinal digestion on bioactive compounds, bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder. / Gómez-García, Ricardo ; Vilas-Boas, Ana A.; Machado, Manuela; Campos, Débora A.; Aguilar, Cristóbal N.; Madureira, Ana R.; Pintado, Manuela.

In: Food Bioscience, Vol. 47, 101726, 06.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Impact of simulated in vitro gastrointestinal digestion on bioactive compounds, bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder

AU - Gómez-García, Ricardo

AU - Vilas-Boas, Ana A.

AU - Machado, Manuela

AU - Campos, Débora A.

AU - Aguilar, Cristóbal N.

AU - Madureira, Ana R.

AU - Pintado, Manuela

N1 - Funding Information: The authors would like to thank the National Council of Science and Technology (CONACyT, Mexico) for PhD fellowship support granted to Gómez-García Ricardo and also the authors would like to thank to the project MultiBiorefinery: Estratégias multiuso para a valorização de uma gama alargada de subprodutos agroflorestais e das pescas: Um passo em frente na criação de uma biorrefinaria" financiado pelo Programa Operacional Competitividade e Internacionalização (POCI-01-0145-FEDER-016403) e pelo Programa Operacional Regional de Lisboa (LISBOA-01-0145-FEDER-016403), na sua componente FEDER e pela Fundação para a Ciência e Tecnologia, I.P. na componente nacional (SAICTPAC/0040/2015). Publisher Copyright: © 2022

PY - 2022/6

Y1 - 2022/6

N2 - The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products, considering (i) the recovery and accessibility indexes, (ii) the changes on antioxidant activity, and (iii) the prebiotic effect. Throughout exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were observed. However, these both parameters exhibited stable accessibility, accounting with 81.89%, 76.55%, and 54.07% for TPC, ABTS and DPPH, respectively. After gastrointestinal digestion, the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and Lactobacillus strains, possibly associated with the high content of simple sugar (glucose and fructose). This fraction also showed to be safe on Caco-2 intestinal cells. These findings suggest that MPJ might be used as a potential food functional ingredient.

AB - The objectives of this research work were to evaluate the effect of in vitro gastrointestinal digestion (GIT) on melon peel juice (MPJ) powder from fruit processing industry by-products, considering (i) the recovery and accessibility indexes, (ii) the changes on antioxidant activity, and (iii) the prebiotic effect. Throughout exposition to GIT conditions a decrease on the total phenolic content (TPC = 65.31%) and antioxidant activity by ABTS = 39.77% and DPPH = 45.91% were observed. However, these both parameters exhibited stable accessibility, accounting with 81.89%, 76.55%, and 54.07% for TPC, ABTS and DPPH, respectively. After gastrointestinal digestion, the non-absorbed fraction exhibited a positive impact on the growth of Bifidobacterium and Lactobacillus strains, possibly associated with the high content of simple sugar (glucose and fructose). This fraction also showed to be safe on Caco-2 intestinal cells. These findings suggest that MPJ might be used as a potential food functional ingredient.

KW - Functional ingredients

KW - Melon by-products

KW - Phenolic antioxidants

KW - Prebiotic effect

KW - Simulated digestion

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U2 - 10.1016/j.fbio.2022.101726

DO - 10.1016/j.fbio.2022.101726

M3 - Article

AN - SCOPUS:85130341046

VL - 47

JO - Food Bioscience

JF - Food Bioscience

SN - 2212-4292

M1 - 101726

ER -

Impact of simulated in vitro gastrointestinal digestion on bioactive compounds, bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder

Abstract

Keywords

Access to Document

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CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

MultiBiorefinery: Multi-purpose strategies for broadband agro-forest and fisheries by-products valorization: a step

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Impact of simulated in vitro gastrointestinal digestion on bioactive compounds, bioactivity and cytotoxicity of melon (Cucumis melo L. inodorus) peel juice powder

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

CBQF Multianual Funding: Centre for Biotechnology and Fine Chemistry

MultiBiorefinery: Multi-purpose strategies for broadband agro-forest and fisheries by-products valorization: a step

Cite this