In silica analysis of gad gene presence in classic and next-generation probiotics

Rita Vedor*, Joana Cristina Barbosa, Daniela Machado, José Carlos Andrade, Ana Maria Gomes

*Corresponding author for this work

Research output: Contribution to conferencePosterpeer-review

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Abstract

Gamma-aminobutyric acid (GABA) is primarily produced in microbes through a GAD enzyme-mediated decarboxylation of L-glutamate, with pyridoxal 5’- phosphate (PLP) as a co-factor (Yogeswara et al., 2020). While studies have focused on pathogenic bacteria, metagenomic analysis shows gut-colonising bacteria also encode the gad gene. The GAD enzyme, encoded by gadA, gadB, or both, mediates GABA synthesis in bacterial cells. Glutamate enters the cell via an antiporter channel for decarboxylation, and the final product, GABA, is secreted through a glutamate/GABA antiporter, encoded by the gadC gene .
Original languageEnglish
Pages1-1
Number of pages1
Publication statusPublished - Jul 2024
EventEncontro Ciência 2024: +Ciência para Uma Só Saúde e bem-estar global - Alfândega do Porto, Porto, Portugal
Duration: 3 Jul 20245 Jul 2024
https://www.encontrociencia.pt/

Conference

ConferenceEncontro Ciência 2024
Country/TerritoryPortugal
CityPorto
Period3/07/245/07/24
Internet address

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