In vitro studies with 'acatalasemic-like' erythrocytes and hydrogen peroxide: Attention to the formation of lysis resistant erythrocytes

H. Nascimento*, L. Belo, J. Fernandes, S. Rocha, A. Quintanilha, A. Santos-Silva

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Hemolysis assays, using hydrogen peroxide as an oxidant injury agent and sodium azide as a catalase inhibitor, were performed to evaluate how assay conditions affect the development of lysis resistant erythrocytes. The concentration of hydrogen peroxide should be carefully selected for use in hemolysis assays, as it was found to affect the number of water resistant erythrocytes.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalInternational Journal of Laboratory Hematology
Volume32
Issue number1 PART.2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Erythrocyte morphology
  • Erythrocytes
  • Hemolysis tests
  • Hydrogen peroxide
  • Oxidative stress

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