Increased circulating platelet microparticles as a potential biomarker in asthma

D. Duarte; T. Taveira-Gomes; O. Sokhatska; C. Palmares; R. Costa; R. Negrão; J. T. Guimarães; L. Delgado; R. Soares; A. Moreira

doi:10.1111/all.12190

Increased circulating platelet microparticles as a potential biomarker in asthma

D. Duarte^*, T. Taveira-Gomes, O. Sokhatska, C. Palmares, R. Costa, R. Negrão, J. T. Guimarães, L. Delgado, R. Soares, A. Moreira

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Background Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. Methods In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Results Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b - /AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). Conclusions We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

Original language	English
Pages (from-to)	1073-1075
Number of pages	3
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	68
Issue number	8
DOIs	https://doi.org/10.1111/all.12190
Publication status	Published - Aug 2013
Externally published	Yes

Keywords

apoptosis
asthma
endothelial and platelet microparticles
sICAM-1
VEGF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/all.12190

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title = "Increased circulating platelet microparticles as a potential biomarker in asthma",

abstract = "Background Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. Methods In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Results Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b - /AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). Conclusions We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.",

keywords = "apoptosis, asthma, endothelial and platelet microparticles, sICAM-1, VEGF",

author = "D. Duarte and T. Taveira-Gomes and O. Sokhatska and C. Palmares and R. Costa and R. Negr{\~a}o and Guimar{\~a}es, {J. T.} and L. Delgado and R. Soares and A. Moreira",

year = "2013",

month = aug,

doi = "10.1111/all.12190",

language = "English",

volume = "68",

pages = "1073--1075",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

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TY - JOUR

T1 - Increased circulating platelet microparticles as a potential biomarker in asthma

AU - Duarte, D.

AU - Taveira-Gomes, T.

AU - Sokhatska, O.

AU - Palmares, C.

AU - Costa, R.

AU - Negrão, R.

AU - Guimarães, J. T.

AU - Delgado, L.

AU - Soares, R.

AU - Moreira, A.

PY - 2013/8

Y1 - 2013/8

N2 - Background Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. Methods In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Results Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b - /AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). Conclusions We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

AB - Background Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. Methods In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Results Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b - /AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). Conclusions We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

KW - apoptosis

KW - asthma

KW - endothelial and platelet microparticles

KW - sICAM-1

KW - VEGF

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DO - 10.1111/all.12190

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SN - 0105-4538

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JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 8

ER -

Increased circulating platelet microparticles as a potential biomarker in asthma

Abstract

Keywords

UN SDGs

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