TY - JOUR
T1 - Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles
AU - Sousa, Diana
AU - Lima, Raquel T.
AU - Vasconcelos, M. Helena
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Extracellular vesicles (EVs) are nanosized particles (100-1000. nm) enclosed by a phospholipid bilayer that have been described as important mediators of intercellular communication. The role of EVs in oncobiology has been extensively studied, including their contribution to the horizontal transfer of drug resistance from drug-resistant to drug-sensitive cancer cells. This review focuses on the EVs cargo responsible for this intercellular transfer of drug resistance; namely, drug-efflux pumps, miRNAs, long noncoding RNAs (lncRNAs), and other mediators. Additionally, the known molecular mechanisms and features of this transfer are discussed. This is an emerging area of research and we highlight topics that need to be further studied to fully understand and counteract the intercellular transfer of drug resistance mediated by EVs. EVs shed by drug-resistant (donor) cells contribute to the dissemination of CDR by transferring their cargo to drug-sensitive (recipient) cells.The cargo of the drug-resistant EVs may be selectively packaged and may include drug-efflux pumps, miRNAs, or lncRNAs.The drug-efflux pumps transferred by EVs to drug-sensitive cells are functional in the recipient cells.Drug-efflux pumps carried by EVs may be responsible for the sequestration of drugs in those EVs.EVs may protect miRNAs from the action of RNase.
AB - Extracellular vesicles (EVs) are nanosized particles (100-1000. nm) enclosed by a phospholipid bilayer that have been described as important mediators of intercellular communication. The role of EVs in oncobiology has been extensively studied, including their contribution to the horizontal transfer of drug resistance from drug-resistant to drug-sensitive cancer cells. This review focuses on the EVs cargo responsible for this intercellular transfer of drug resistance; namely, drug-efflux pumps, miRNAs, long noncoding RNAs (lncRNAs), and other mediators. Additionally, the known molecular mechanisms and features of this transfer are discussed. This is an emerging area of research and we highlight topics that need to be further studied to fully understand and counteract the intercellular transfer of drug resistance mediated by EVs. EVs shed by drug-resistant (donor) cells contribute to the dissemination of CDR by transferring their cargo to drug-sensitive (recipient) cells.The cargo of the drug-resistant EVs may be selectively packaged and may include drug-efflux pumps, miRNAs, or lncRNAs.The drug-efflux pumps transferred by EVs to drug-sensitive cells are functional in the recipient cells.Drug-efflux pumps carried by EVs may be responsible for the sequestration of drugs in those EVs.EVs may protect miRNAs from the action of RNase.
UR - http://www.scopus.com/inward/record.url?scp=84942521471&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2015.08.002
DO - 10.1016/j.molmed.2015.08.002
M3 - Review article
C2 - 26432017
AN - SCOPUS:84942521471
SN - 1471-4914
VL - 21
SP - 595
EP - 608
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 10
M1 - 1063
ER -
