TY - JOUR
T1 - Living with sulfonamides
T2 - a diverse range of mechanisms observed in bacteria
AU - Nunes, Olga C.
AU - Manaia, Célia M.
AU - Kolvenbach, Boris A.
AU - Corvini, Philippe F.X.
N1 - Funding Information:
This work was supported by Base Funding-UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE) funded by national funds through Fundação para a Ciência e a Tecnologia (FCT)/MCTES (PIDDAC), and FCT project UID/Multi/50016/2019 (Associate Laboratory CBQF). We also received support from the European Union’s Horizon 2020 research and innovation program under grant agreement 826244. Acknowledgments
Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Abstract: Sulfonamides are the oldest class of synthetic antibiotics still in use in clinical and veterinary settings. The intensive utilization of sulfonamides has been leading to the widespread contamination of the environment with these xenobiotic compounds. Consequently, in addition to pathogens and commensals, also bacteria inhabiting a wide diversity of environmental compartments have been in contact with sulfonamides for almost 90 years. This review aims at giving an overview of the effect of sulfonamides on bacterial cells, including the strategies used by bacteria to cope with these bacteriostatic agents. These include mechanisms of antibiotic resistance, co-metabolic transformation, and partial or total mineralization of sulfonamides. Possible implications of these mechanisms on the ecosystems and dissemination of antibiotic resistance are also discussed. Key points: • Sulfonamides are widespread xenobiotic pollutants; • Target alteration is the main sulfonamide resistance mechanism observed in bacteria; • Sulfonamides can be modified, degraded, or used as nutrients by some bacteria.
AB - Abstract: Sulfonamides are the oldest class of synthetic antibiotics still in use in clinical and veterinary settings. The intensive utilization of sulfonamides has been leading to the widespread contamination of the environment with these xenobiotic compounds. Consequently, in addition to pathogens and commensals, also bacteria inhabiting a wide diversity of environmental compartments have been in contact with sulfonamides for almost 90 years. This review aims at giving an overview of the effect of sulfonamides on bacterial cells, including the strategies used by bacteria to cope with these bacteriostatic agents. These include mechanisms of antibiotic resistance, co-metabolic transformation, and partial or total mineralization of sulfonamides. Possible implications of these mechanisms on the ecosystems and dissemination of antibiotic resistance are also discussed. Key points: • Sulfonamides are widespread xenobiotic pollutants; • Target alteration is the main sulfonamide resistance mechanism observed in bacteria; • Sulfonamides can be modified, degraded, or used as nutrients by some bacteria.
KW - Antibiotic resistance
KW - Biodegradation
KW - Biotransformation
KW - Xenobiotic
UR - http://www.scopus.com/inward/record.url?scp=85096004891&partnerID=8YFLogxK
U2 - 10.1007/s00253-020-10982-5
DO - 10.1007/s00253-020-10982-5
M3 - Review article
C2 - 33175245
AN - SCOPUS:85096004891
SN - 0175-7598
VL - 104
SP - 10389
EP - 10408
JO - Applied Microbiology and Biotechnology
JF - Applied Microbiology and Biotechnology
IS - 24
ER -