Luminescent calcium phosphate bioceramics doped with europium derived from fish industry byproducts

Clara Piccirillo*, Alessio Adamiano, David M. Tobaldi, Marco Montalti, Jeannette Manzi, Paula M. Lima Castro, Silvia Panseri, Monica Montesi, Simone Sprio, Anna Tampieri, Michele Iafisco

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The recovery of valuable compounds from byproducts is at present a priority topic for social, environmental, and economic reasons. In this work we report for the first time the preparation of luminescent calcium phosphate (CaP) bioceramics from waste codfish bones. Codfish bones were treated in aqueous Eu(NO3)3 solutions of different concentrations, followed by thermal treatment at either 700°C or 1100°C. The resulting materials consisted of hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) and a small amount of Eu2O3. Chemical and structural characterization showed that the Eu ions were successfully introduced into the bones and, hence, in the thermally treated CaP phases obtained from them, although mainly in the β-TCP lattice. Photoluminescence investigation revealed that all the materials are luminescent, with samples treated at 1100°C having more intense luminescence than those prepared at 700°C. In vitro evaluation of cell-materials interaction indicated that all the samples displayed good cytocompatibility toward osteoblast cells. This work demonstrates that a simple and effective process, employing Eu as a dopant, can convert fish industry byproducts into highly valuable luminescent CaP bioceramics, having potential applications in biology and medicine for bio-imaging.

Original languageEnglish
Pages (from-to)3402-3414
Number of pages13
JournalJournal of the American Ceramic Society
Issue number8
Publication statusPublished - Aug 2017


  • Calcium phosphates
  • Europium
  • Luminescence
  • Waste valorisation
  • β-tricalcium phosphate


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