TY - JOUR
T1 - Memory awareness in patients with major depressive disorder
AU - Mendes, Tiago
AU - Cardoso, Sandra
AU - Guerreiro, Manuela
AU - Maroco, João
AU - Silva, Dina
AU - Alves, Luísa
AU - Schmand, Ben
AU - Couto, Frederico Simões do
AU - Figueira, Maria Luísa
AU - Mendonça, Alexandre de
N1 - Funding Information:
The authors thank Memoclínica for the facilities provided and Dr. Catarina Alvarez for collaboration in neuropsychological testing. This work was supported by a grant from Fundação para a Ciência e Tecnologia (FCT) - PTDC/MED-NEU/27946/2017 . The funding institution had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/5
Y1 - 2021/5
N2 - Background: Subjective Memory Complaints (SMC) along with cognitive deficits are frequently observed in patients with Major Depressive Disorder (MDD). The relationship between SMC and objective memory performance in patients with MDD was evaluated, in comparison with patients with Mild Cognitive Impairment due to Alzheimer's Disease (MCI-AD) and healthy controls (HC). Methods: Patients with MDD (n = 47), MCI-AD (n = 43) and HC (n = 45) were assessed with a self-report memory complaints scale (SMCS) and underwent a comprehensive clinical and neuropsychological assessment. A discrepancy score between the Logical Memory delayed recall and the SMCS total score was calculated as a measure of memory awareness. Results: Patients with MDD (12.5 ± 4.4) and patients with MCI-AD (10.9 ± 4.1) had not significantly different SMCS total scores, whereas HC showed significantly lower scores (4.0 ± 3.0). As much as 74.5% of patients with MDD patients and 65.1% of patients with MCI-AD reported prominent memory complaints, whereas only 4.4% of HC did. Patients with MDD had relatively preserved memory tests, resulting in a higher discrepancy score than both patients with MCI-AD and HC. The SMCS total score correlated positively with depressive symptoms in the 3 groups of participants. Conclusions: Patients with MDD showed inaccurate memory self-awareness as they under-estimated their memory functioning, a pattern distinct from both patients with MCI-AD and HC.
AB - Background: Subjective Memory Complaints (SMC) along with cognitive deficits are frequently observed in patients with Major Depressive Disorder (MDD). The relationship between SMC and objective memory performance in patients with MDD was evaluated, in comparison with patients with Mild Cognitive Impairment due to Alzheimer's Disease (MCI-AD) and healthy controls (HC). Methods: Patients with MDD (n = 47), MCI-AD (n = 43) and HC (n = 45) were assessed with a self-report memory complaints scale (SMCS) and underwent a comprehensive clinical and neuropsychological assessment. A discrepancy score between the Logical Memory delayed recall and the SMCS total score was calculated as a measure of memory awareness. Results: Patients with MDD (12.5 ± 4.4) and patients with MCI-AD (10.9 ± 4.1) had not significantly different SMCS total scores, whereas HC showed significantly lower scores (4.0 ± 3.0). As much as 74.5% of patients with MDD patients and 65.1% of patients with MCI-AD reported prominent memory complaints, whereas only 4.4% of HC did. Patients with MDD had relatively preserved memory tests, resulting in a higher discrepancy score than both patients with MCI-AD and HC. The SMCS total score correlated positively with depressive symptoms in the 3 groups of participants. Conclusions: Patients with MDD showed inaccurate memory self-awareness as they under-estimated their memory functioning, a pattern distinct from both patients with MCI-AD and HC.
KW - Alzheimer's disease
KW - Awareness
KW - Major depression
KW - Memory
KW - Mild cognitive impairment
KW - Subjective memory complaints
UR - http://www.scopus.com/inward/record.url?scp=85103096285&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2021.03.016
DO - 10.1016/j.jpsychires.2021.03.016
M3 - Article
C2 - 33774535
SN - 0022-3956
VL - 137
SP - 411
EP - 418
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -