Metabolic profile and biological activities of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco: Studies on the essential oil and polar extracts

Patrícia Costa; Sandra Gonçalves; Patrícia Valentão; Paula B. Andrade; Carlos Almeida; José M.F. Nogueira; Anabela Romano

doi:10.1016/j.foodchem.2013.05.055

Metabolic profile and biological activities of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco: Studies on the essential oil and polar extracts

Patrícia Costa, Sandra Gonçalves, Patrícia Valentão, Paula B. Andrade, Carlos Almeida, José M.F. Nogueira, Anabela Romano^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

We investigated the metabolic profile and biological activities of the essential oil and polar extracts of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco collected in south Portugal. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oxygen-containing monoterpenes was the principal group of compounds identified in the essential oil. Camphor (40.6%) and fenchone (38.0%) were found as the major constituents. High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis allowed the identification of hydroxycinnamic acids (3-O-caffeoylquinic, 4-O-caffeoylquinic, 5-O-caffeoylquinic and rosmarinic acids) and flavones (luteolin and apigenin) in the polar extracts, with rosmarinic acid being the main compound in most of them. The bioactive compounds from L. pedunculata polar extracts were the most efficient free-radical scavengers, Fe²⁺ chelators and inhibitors of malondialdehyde production, while the essential oil was the most active against acetylcholinesterase. Our results reveal that the subspecies of L. pedunculata studied is a potential source of active metabolites with a positive effect on human health.

Original language	English
Pages (from-to)	2501-2506
Number of pages	6
Journal	Food Chemistry
Volume	141
Issue number	3
DOIs	https://doi.org/10.1016/j.foodchem.2013.05.055
Publication status	Published - 2013
Externally published	Yes

Keywords

Alzheimer's disease
Anti-cholinesterases
Antioxidants
Essential oil
Lavandula pedunculata subsp. lusitanica
Phenolic compounds

Access to Document

10.1016/j.foodchem.2013.05.055

Cite this

@article{0120bd4e37f24987a111b9d94666914a,

title = "Metabolic profile and biological activities of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco: Studies on the essential oil and polar extracts",

abstract = "We investigated the metabolic profile and biological activities of the essential oil and polar extracts of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco collected in south Portugal. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oxygen-containing monoterpenes was the principal group of compounds identified in the essential oil. Camphor (40.6%) and fenchone (38.0%) were found as the major constituents. High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis allowed the identification of hydroxycinnamic acids (3-O-caffeoylquinic, 4-O-caffeoylquinic, 5-O-caffeoylquinic and rosmarinic acids) and flavones (luteolin and apigenin) in the polar extracts, with rosmarinic acid being the main compound in most of them. The bioactive compounds from L. pedunculata polar extracts were the most efficient free-radical scavengers, Fe2+ chelators and inhibitors of malondialdehyde production, while the essential oil was the most active against acetylcholinesterase. Our results reveal that the subspecies of L. pedunculata studied is a potential source of active metabolites with a positive effect on human health.",

keywords = "Alzheimer's disease, Anti-cholinesterases, Antioxidants, Essential oil, Lavandula pedunculata subsp. lusitanica, Phenolic compounds",

author = "Patr{\'i}cia Costa and Sandra Gon{\c c}alves and Patr{\'i}cia Valent{\~a}o and Andrade, {Paula B.} and Carlos Almeida and Nogueira, {Jos{\'e} M.F.} and Anabela Romano",

note = "Funding Information: P. Costa, S. Gon{\c c}alves and C. Almeida acknowledge grants from the Portuguese Science and Technology Foundation (FCT) (SFRH/BD/63505/2009, SFRH/BPD/31534/2006 and SFRH/BD/69951/2010, respectively). P. Valent{\~a}o and P.B. Andrade are grateful to FCT for Grant No. PEst-C/EQB/LA0006/2011.",

year = "2013",

doi = "10.1016/j.foodchem.2013.05.055",

language = "English",

volume = "141",

pages = "2501--2506",

journal = "Food Chemistry",

issn = "0308-8146",

publisher = "Elsevier Ltd.",

number = "3",

}

TY - JOUR

T1 - Metabolic profile and biological activities of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco

T2 - Studies on the essential oil and polar extracts

AU - Costa, Patrícia

AU - Gonçalves, Sandra

AU - Valentão, Patrícia

AU - Andrade, Paula B.

AU - Almeida, Carlos

AU - Nogueira, José M.F.

AU - Romano, Anabela

N1 - Funding Information: P. Costa, S. Gonçalves and C. Almeida acknowledge grants from the Portuguese Science and Technology Foundation (FCT) (SFRH/BD/63505/2009, SFRH/BPD/31534/2006 and SFRH/BD/69951/2010, respectively). P. Valentão and P.B. Andrade are grateful to FCT for Grant No. PEst-C/EQB/LA0006/2011.

PY - 2013

Y1 - 2013

N2 - We investigated the metabolic profile and biological activities of the essential oil and polar extracts of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco collected in south Portugal. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oxygen-containing monoterpenes was the principal group of compounds identified in the essential oil. Camphor (40.6%) and fenchone (38.0%) were found as the major constituents. High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis allowed the identification of hydroxycinnamic acids (3-O-caffeoylquinic, 4-O-caffeoylquinic, 5-O-caffeoylquinic and rosmarinic acids) and flavones (luteolin and apigenin) in the polar extracts, with rosmarinic acid being the main compound in most of them. The bioactive compounds from L. pedunculata polar extracts were the most efficient free-radical scavengers, Fe2+ chelators and inhibitors of malondialdehyde production, while the essential oil was the most active against acetylcholinesterase. Our results reveal that the subspecies of L. pedunculata studied is a potential source of active metabolites with a positive effect on human health.

AB - We investigated the metabolic profile and biological activities of the essential oil and polar extracts of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco collected in south Portugal. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oxygen-containing monoterpenes was the principal group of compounds identified in the essential oil. Camphor (40.6%) and fenchone (38.0%) were found as the major constituents. High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis allowed the identification of hydroxycinnamic acids (3-O-caffeoylquinic, 4-O-caffeoylquinic, 5-O-caffeoylquinic and rosmarinic acids) and flavones (luteolin and apigenin) in the polar extracts, with rosmarinic acid being the main compound in most of them. The bioactive compounds from L. pedunculata polar extracts were the most efficient free-radical scavengers, Fe2+ chelators and inhibitors of malondialdehyde production, while the essential oil was the most active against acetylcholinesterase. Our results reveal that the subspecies of L. pedunculata studied is a potential source of active metabolites with a positive effect on human health.

KW - Alzheimer's disease

KW - Anti-cholinesterases

KW - Antioxidants

KW - Essential oil

KW - Lavandula pedunculata subsp. lusitanica

KW - Phenolic compounds

UR - http://www.scopus.com/inward/record.url?scp=84879249720&partnerID=8YFLogxK

U2 - 10.1016/j.foodchem.2013.05.055

DO - 10.1016/j.foodchem.2013.05.055

M3 - Article

C2 - 23870987

AN - SCOPUS:84879249720

SN - 0308-8146

VL - 141

SP - 2501

EP - 2506

JO - Food Chemistry

JF - Food Chemistry

IS - 3

ER -

Metabolic profile and biological activities of Lavandula pedunculata subsp. lusitanica (Chaytor) Franco: Studies on the essential oil and polar extracts

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this