TY - GEN
T1 - Mineralization of chitosan membrane using a double diffusion system for bone related applications
AU - Gomes, S.
AU - Boulon, M. E.
AU - Oliveira, A. L.
AU - Leonor, I. B.
AU - Mano, J. F.
AU - Reis, R. L.
PY - 2008
Y1 - 2008
N2 - Chitosan membranes were subjected to a pre-treatment in a double diffusion system, with a calcium solution in one chamber and a phosphate solution in the other chamber. Both chambers were separated by the chitosan membrane and subject to three mineralization periods (5, 10 and 15 minutes). After this pre-treatment the bioactivity of the different calcium phosphate coatings formed was tested for different periods of immersion time, 7, 14 and 21 days at room temperature and 37°C, in acellular simulated body fluid (1.0x). The results obtained demonstrated that the calcium phosphate coatings formed during the pre-treatment process are bioactive. It was found that the calcification is effective just in the side of the membrane exposed to the calcium solution chamber. This enabled to develop membranes with asymmetric osteoinductive properties that can be useful in different orthopedic applications.
AB - Chitosan membranes were subjected to a pre-treatment in a double diffusion system, with a calcium solution in one chamber and a phosphate solution in the other chamber. Both chambers were separated by the chitosan membrane and subject to three mineralization periods (5, 10 and 15 minutes). After this pre-treatment the bioactivity of the different calcium phosphate coatings formed was tested for different periods of immersion time, 7, 14 and 21 days at room temperature and 37°C, in acellular simulated body fluid (1.0x). The results obtained demonstrated that the calcium phosphate coatings formed during the pre-treatment process are bioactive. It was found that the calcification is effective just in the side of the membrane exposed to the calcium solution chamber. This enabled to develop membranes with asymmetric osteoinductive properties that can be useful in different orthopedic applications.
KW - Calcium-phosphate coating
KW - Chitosan membranes
KW - Double diffusion system
UR - http://www.scopus.com/inward/record.url?scp=60349086084&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/msf.587-588.77
DO - 10.4028/www.scientific.net/msf.587-588.77
M3 - Conference contribution
AN - SCOPUS:60349086084
SN - 9780878493739
VL - 587-588
T3 - Materials Science Forum
SP - 77
EP - 81
BT - Advanced Materials Forum IV - Selected, peer reviewed papers from the IV International Materials Symposium Materiais 2007 and XIII Encontro da Sociedade Portuguesa de Materiais - SPM
A2 - Marques, Antonio Torres
A2 - Baptista, Antonio Paulo Monteiro
A2 - Silva, Antonio Fernando
A2 - Alves, Fernando Jorge Lino
A2 - Sa, Carlos
A2 - Malheiros, Luis Filipe
A2 - Vieira, Manuel
PB - Trans Tech Publications Ltd
T2 - Advanced Materials Forum IV - Selected, peer reviewed papers from the 4th International Materials Symposium Materiais 2007 and 8th Encontro da Sociedade Portuguesa de Materiais - SPM
Y2 - 1 April 2007 through 4 April 2007
ER -