Nerve-cancer cell cross-talk: A novel promoter of tumor progression

Phillip Jobling; Jay Pundavela; Sonia M.R. Oliveira; Séverine Roselli; Marjorie M. Walker; Hubert Hondermarck

doi:10.1158/0008-5472.CAN-14-3180

Nerve-cancer cell cross-talk: A novel promoter of tumor progression

Phillip Jobling, Jay Pundavela, Sonia M.R. Oliveira, Séverine Roselli, Marjorie M. Walker, Hubert Hondermarck^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

204 Citations (Scopus)

Abstract

Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells. Cancer Res; 75(9); 1777-81.

Original language	English
Pages (from-to)	1777-1781
Number of pages	5
Journal	Cancer Research
Volume	75
Issue number	9
DOIs	https://doi.org/10.1158/0008-5472.CAN-14-3180
Publication status	Published - 1 May 2015
Externally published	Yes

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Cite this

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title = "Nerve-cancer cell cross-talk: A novel promoter of tumor progression",

abstract = "Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells. Cancer Res; 75(9); 1777-81.",

author = "Phillip Jobling and Jay Pundavela and Oliveira, {Sonia M.R.} and S{\'e}verine Roselli and Walker, {Marjorie M.} and Hubert Hondermarck",

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T1 - Nerve-cancer cell cross-talk

T2 - A novel promoter of tumor progression

AU - Jobling, Phillip

AU - Pundavela, Jay

AU - Oliveira, Sonia M.R.

AU - Roselli, Séverine

AU - Walker, Marjorie M.

AU - Hondermarck, Hubert

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells. Cancer Res; 75(9); 1777-81.

AB - Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells. Cancer Res; 75(9); 1777-81.

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AN - SCOPUS:84942908660

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JO - Cancer Research

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Nerve-cancer cell cross-talk: A novel promoter of tumor progression

Abstract

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